| Acute and chronic effects of marijuana smoking on pulmonary alveolar permeability. | |
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MedLine Citation:
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PMID: 7776849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary clearance of technetium (99mTc)-labeled diethylene triamine pentaacetate (DTPA), a sensitive test of alveolar epithelial permeability, was measured twice in 34 healthy subjects, including 10 control nonsmokers (NS), 10 habitual smokers of marijuana alone (MS) (> or = 10 joints/wk), 9 regular smokers of tobacco alone (TS) (> or = 15 cigarettes/day) and 4 habitual smokers of both marijuana and tobacco (MTS). In smokers, the first study was performed after > or = 12 hrs of abstinence from smoking to assess chronic effects of marijuana and/or tobacco smoking on alveolar permeability; the second study was performed within 15 min of smoking to assess possible acute effects. TS exhibited abnormally rapid 99mTc-DTPA clearance after > or = 12 hours of abstinence, indicating an increase in pulmonary epithelial permeability, consistent with chronic tobacco-induced lung injury. MS showed a more modest and less consistent chronic effect than TS on 99mTc-DTPA clearance, suggesting a more variable and smaller degree of marijuana-induced lung injury. No acute effect of tobacco or marijuana smoking on 99mTc-DTPA clearance was apparent. Concomitant habitual smoking of marijuana and tobacco had no additive effect on alveolar permeability. |
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Authors:
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E Gil; B Chen; E Kleerup; M Webber; D P Tashkin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 56 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-07-11 Completed Date: 1995-07-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2193-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, UCLA School of Medicine 90095, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Membrane Permeability* Cohort Studies Female Humans Male Marijuana Smoking / adverse effects*, metabolism, pathology Plants, Toxic Pulmonary Alveoli / metabolism*, pathology Smoking / adverse effects, metabolism, pathology Technetium Tc 99m Pentetate / pharmacokinetics Tobacco |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA 03018/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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65454-61-7/Technetium Tc 99m Pentetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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