Document Detail

Acute and chronic effects of marijuana smoking on pulmonary alveolar permeability.
MedLine Citation:
PMID:  7776849     Owner:  NLM     Status:  MEDLINE    
Pulmonary clearance of technetium (99mTc)-labeled diethylene triamine pentaacetate (DTPA), a sensitive test of alveolar epithelial permeability, was measured twice in 34 healthy subjects, including 10 control nonsmokers (NS), 10 habitual smokers of marijuana alone (MS) (> or = 10 joints/wk), 9 regular smokers of tobacco alone (TS) (> or = 15 cigarettes/day) and 4 habitual smokers of both marijuana and tobacco (MTS). In smokers, the first study was performed after > or = 12 hrs of abstinence from smoking to assess chronic effects of marijuana and/or tobacco smoking on alveolar permeability; the second study was performed within 15 min of smoking to assess possible acute effects. TS exhibited abnormally rapid 99mTc-DTPA clearance after > or = 12 hours of abstinence, indicating an increase in pulmonary epithelial permeability, consistent with chronic tobacco-induced lung injury. MS showed a more modest and less consistent chronic effect than TS on 99mTc-DTPA clearance, suggesting a more variable and smaller degree of marijuana-induced lung injury. No acute effect of tobacco or marijuana smoking on 99mTc-DTPA clearance was apparent. Concomitant habitual smoking of marijuana and tobacco had no additive effect on alveolar permeability.
E Gil; B Chen; E Kleerup; M Webber; D P Tashkin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  56     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1995  
Date Detail:
Created Date:  1995-07-11     Completed Date:  1995-07-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2193-9     Citation Subset:  IM    
Department of Medicine, UCLA School of Medicine 90095, USA.
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MeSH Terms
Cell Membrane Permeability*
Cohort Studies
Marijuana Smoking / adverse effects*,  metabolism,  pathology
Plants, Toxic
Pulmonary Alveoli / metabolism*,  pathology
Smoking / adverse effects,  metabolism,  pathology
Technetium Tc 99m Pentetate / pharmacokinetics
Grant Support
Reg. No./Substance:
65454-61-7/Technetium Tc 99m Pentetate

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