| Acute and chronic effects of exercise on inflammatory markers and B-type natriuretic peptide in patients with coronary artery disease. | |
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MedLine Citation:
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PMID: 20835904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Few studies have prospectively addressed the effects of exercise in the inflammatory activity of patients with coronary artery disease (CAD). We sought to evaluate the consequences of an acute bout of exercise on inflammatory markers and BNP in untrained CAD patients before and after randomization to a training program. METHODS: 34 CAD patients underwent a 50-min acute exercise session on a cycle-ergometer at 65% peak oxygen uptake before and after blood sampling. They were then randomized to a 4-month chronic exercise program (15 patients) or general lifestyle recommendations (19 patients), undergoing a new acute session of exercise after that. RESULTS: In the overall population, acute exercise caused a significant increase in C-reactive protein [CRP; 1.79 (4.49) vs. 1.94 (4.89) mg/L, P < 0.001], monokine induced by interferon-γ [Mig; 351 (324) vs. 373 (330) pg/mL, P = 0.027] and vascular adhesion molecule-1 [VCAM-1; 226 (82) vs. 252 (110) pg/mL, P = 0.02]. After 4-months, in exercise-trained patients, there was a significant decrease in the inflammatory response provoked by the acute exercise compared to patients in the control group reflected by a significant decrease in the differences between rest and post-exercise levels of CRP [-0.29 (0.84) mg/L vs. -0.11 (0.21) mg/L, P = 0.05]. Resting BNP was also significantly lower in exercise-trained patients when compared to untrained controls [15.6 (16.2) vs. 9.7 (11.4) pg/mL, P = 0.04 and 19.2 (27.8) vs. 23.2 (27.5) pg/mL, P = 0.76; respectively]. CONCLUSIONS: Chronic exercise training might partially reverse the inflammatory response caused by acute exercise in CAD patients. These results suggest that regular exercise is an important nonpharmacological strategy to the improvement in inflammation in CAD patients. |
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Authors:
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Juliano Lara Fernandes; Carlos Vicente Serrano; Flavia Toledo; Maria Fernanda Hunziker; Augusto Zamperini; Fabio H Teo; Romulo T Oliveira; Maria Heloisa Blotta; Maria Urbana Rondon; Carlos Eduardo Negrão |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-09-12 |
Journal Detail:
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Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: 100 ISSN: 1861-0692 ISO Abbreviation: Clin Res Cardiol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-18 Completed Date: 2011-05-16 Revised Date: 2011-06-15 |
Medline Journal Info:
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Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 77-84 Citation Subset: IM |
Affiliation:
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University of Campinas (Unicamp), R. Antonio Lapa 1032, Campinas, SP, 13025-242, Brazil. jlaraf@fcm.unicamp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Biological Markers / blood Chronic Disease Coronary Artery Disease / blood*, complications, physiopathology* Cytokines / blood* Exercise* Exercise Test Female Humans Inflammation / blood*, complications, physiopathology* Male Middle Aged Natriuretic Peptide, Brain / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cytokines; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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