Document Detail

Acute and chronic effects of exercise on inflammatory markers and B-type natriuretic peptide in patients with coronary artery disease.
MedLine Citation:
PMID:  20835904     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Few studies have prospectively addressed the effects of exercise in the inflammatory activity of patients with coronary artery disease (CAD). We sought to evaluate the consequences of an acute bout of exercise on inflammatory markers and BNP in untrained CAD patients before and after randomization to a training program.
METHODS: 34 CAD patients underwent a 50-min acute exercise session on a cycle-ergometer at 65% peak oxygen uptake before and after blood sampling. They were then randomized to a 4-month chronic exercise program (15 patients) or general lifestyle recommendations (19 patients), undergoing a new acute session of exercise after that.
RESULTS: In the overall population, acute exercise caused a significant increase in C-reactive protein [CRP; 1.79 (4.49) vs. 1.94 (4.89) mg/L, P < 0.001], monokine induced by interferon-γ [Mig; 351 (324) vs. 373 (330) pg/mL, P = 0.027] and vascular adhesion molecule-1 [VCAM-1; 226 (82) vs. 252 (110) pg/mL, P = 0.02]. After 4-months, in exercise-trained patients, there was a significant decrease in the inflammatory response provoked by the acute exercise compared to patients in the control group reflected by a significant decrease in the differences between rest and post-exercise levels of CRP [-0.29 (0.84) mg/L vs. -0.11 (0.21) mg/L, P = 0.05]. Resting BNP was also significantly lower in exercise-trained patients when compared to untrained controls [15.6 (16.2) vs. 9.7 (11.4) pg/mL, P = 0.04 and 19.2 (27.8) vs. 23.2 (27.5) pg/mL, P = 0.76; respectively].
CONCLUSIONS: Chronic exercise training might partially reverse the inflammatory response caused by acute exercise in CAD patients. These results suggest that regular exercise is an important nonpharmacological strategy to the improvement in inflammation in CAD patients.
Juliano Lara Fernandes; Carlos Vicente Serrano; Flavia Toledo; Maria Fernanda Hunziker; Augusto Zamperini; Fabio H Teo; Romulo T Oliveira; Maria Heloisa Blotta; Maria Urbana Rondon; Carlos Eduardo Negrão
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-09-12
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  100     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-18     Completed Date:  2011-05-16     Revised Date:  2011-06-15    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
University of Campinas (Unicamp), R. Antonio Lapa 1032, Campinas, SP, 13025-242, Brazil.
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MeSH Terms
Acute Disease
Biological Markers / blood
Chronic Disease
Coronary Artery Disease / blood*,  complications,  physiopathology*
Cytokines / blood*
Exercise Test
Inflammation / blood*,  complications,  physiopathology*
Middle Aged
Natriuretic Peptide, Brain / blood*
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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