| Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. | |
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MedLine Citation:
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PMID: 20702806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary nitrate (NO(3)(-)) supplementation with beetroot juice (BR) over 4-6 days has been shown to reduce the O(2) cost of submaximal exercise and to improve exercise tolerance. However, it is not known whether shorter (or longer) periods of supplementation have similar (or greater) effects. We therefore investigated the effects of acute and chronic NO(3)(-) supplementation on resting blood pressure (BP) and the physiological responses to moderate-intensity exercise and ramp incremental cycle exercise in eight healthy subjects. Following baseline tests, the subjects were assigned in a balanced crossover design to receive BR (0.5 l/day; 5.2 mmol of NO(3)(-)/day) and placebo (PL; 0.5 l/day low-calorie juice cordial) treatments. The exercise protocol (two moderate-intensity step tests followed by a ramp test) was repeated 2.5 h following first ingestion (0.5 liter) and after 5 and 15 days of BR and PL. Plasma nitrite concentration (baseline: 454 ± 81 nM) was significantly elevated (+39% at 2.5 h postingestion; +25% at 5 days; +46% at 15 days; P < 0.05) and systolic and diastolic BP (baseline: 127 ± 6 and 72 ± 5 mmHg, respectively) were reduced by ∼4% throughout the BR supplementation period (P < 0.05). Compared with PL, the steady-state Vo(2) during moderate exercise was reduced by ∼4% after 2.5 h and remained similarly reduced after 5 and 15 days of BR (P < 0.05). The ramp test peak power and the work rate at the gas exchange threshold (baseline: 322 ± 67 W and 89 ± 15 W, respectively) were elevated after 15 days of BR (331 ± 68 W and 105 ± 28 W; P < 0.05) but not PL (323 ± 68 W and 84 ± 18 W). These results indicate that dietary NO(3)(-) supplementation acutely reduces BP and the O(2) cost of submaximal exercise and that these effects are maintained for at least 15 days if supplementation is continued. |
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Authors:
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Anni Vanhatalo; Stephen J Bailey; Jamie R Blackwell; Fred J DiMenna; Toby G Pavey; Daryl P Wilkerson; Nigel Benjamin; Paul G Winyard; Andrew M Jones |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-08-11 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 299 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-01 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1121-31 Citation Subset: IM |
Affiliation:
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Univ. of Exeter, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaerobic Threshold / drug effects, physiology Beta vulgaris / chemistry* Blood Pressure / drug effects*, physiology* Cross-Over Studies Dietary Supplements Exercise / physiology* Exercise Test Female Humans Lactic Acid / blood Male Nitrates / pharmacology* Nitric Oxide / blood Oxygen Consumption / drug effects, physiology Physical Fitness / physiology* Pulmonary Gas Exchange / physiology Respiratory Mechanics / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 10102-43-9/Nitric Oxide; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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