| Acute and chronic effects of dexfenfluramine on the porcine coronary artery. | |
| | |
MedLine Citation:
|
PMID: 8968327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Experiments were designed to verify whether or not acute or chronic exposure to dexfenfluramine favors the occurrence of coronary vasospasm in vivo or in vitro. Rings of left anterior and left circumflex porcine coronary artery, with and without endothelium, were studied in conventional organ chambers for the measurement of isometric force. The donor pigs were divided into two groups: controls and animals fed for 4 weeks with dexfenfluramine. In each group, one-half of the animals underwent balloon denudation of the left anterior descending coronary artery at the beginning of the study. Coronary angiography was performed at the time of denudation and, in all animals, during the 3rd week of the study. Acutely, dexfenfluramine at concentrations higher than 10(-5) M caused contractions which were blunted by the presence of the endothelium and inhibited by indomethacin (an inhibitor of cyclooxygenase). Chronic treatment with dexfenfluramine did not affect coronary diameter and did not alter the response to intracoronary infusion of serotonin. Chronic treatment with dexfenfluramine reduced the contractions of rings without endothelium to serotonin, but not those to norepinephrine or endothelin. It did not affect endothelium-dependent relaxations in the absence or presence of pertussis toxin to serotonin, UK14304 (alpha-2 adrenergic agonist), adenosine diphosphate or aggregating platelets. Chronic treatment with dexfenfluramine did not modify relaxations of rings without endothelium to SIN-1 (nitric oxide donor; the active metabolite of molsidomine) or adenosine diphosphate. These findings do not support the hypothesis that acute or chronic exposure to dexfenfluramine favors the occurrence of coronary vasospasm. |
| | |
Authors:
|
B Desta; D Schultz; D Ravel; N Laudignon; P M Vanhoutte; C M Boulanger |
Related Documents
:
|
9249237 - Neocuproine, a selective cu(i) chelator, and the relaxation of rat vascular smooth musc... 7400317 - Supersensitivity of atherosclerotic rabbit aorta to ergonovine. mediation by a serotone... 10925237 - The action of diaspirin cross-linked haemoglobin blood substitute on human arterial byp... 3165267 - Calcium antagonistic and spasmolytic activities of a new 1,5-benzothiazepine derivative... 19633027 - Failure to exclude a saccular arch aneurysm during hybrid repair: arch replacement with... 23506637 - Mechanisms of oxidative stress in human aortic aneurysms - association with clinical ri... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: The Journal of pharmacology and experimental therapeutics Volume: 279 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1996 Dec |
Date Detail:
|
Created Date: 1997-01-23 Completed Date: 1997-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1077-85 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight Coronary Vessels / drug effects* Fenfluramine / pharmacology* Male Platelet Aggregation / drug effects Serotonin / pharmacology Swine Vasoconstrictor Agents / pharmacology* Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Vasoconstrictor Agents; 0/Vasodilator Agents; 458-24-2/Fenfluramine; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rapid in vivo metabolism of a methylether derivative of (+/-)-BW373U86: the metabolic fate of [3H]SN...
Next Document: The basolateral organic cation transport system of rabbit kidney proximal tubules. Influence of anor...