Document Detail

Acute and chronic effects of cigarette smoking on arterial stiffness.
MedLine Citation:
PMID:  16036484     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Pulse wave velocity (PWV) is an indicator of arterial stiffness, especially in the aorta, and a marker for vascular damage. Smoking is reported to increase arterial stiffness. We examined the acute and chronic effects of smoking on arterial stiffness by measuring brachial--ankle PWV (baPWV) using an oscillometric method (VP 1000, Colin Co., Komaki, Japan). METHODS: All healthy male subjects (chronic smokers, n=40, 30.3 years old vs non-smokers, n=40, 28.3 years old) smoked two cigarettes (nicotine 1.5 mg) within 10 min and measured blood pressure (BP), heart rate and baPWV at baseline, 5, 15, 30, 45 and 60 min and compared with controls (n=20, 29.3 years old). RESULTS: Systolic BP was higher in chronic smokers than non-smokers or controls. Smoking increased the systolic and diastolic BP and heart rate significantly at 5 min in both chronic smokers and non-smokers as compared with baseline levels or controls (respectively, p<0.001) and returned to baseline level at 15 min. Pulse pressure did not increase significantly. baPWV increased significantly in both chronic smokers and non-smokers at 5 min (12.1--17.3 m/s vs 11.1--12.7 m/sec, respectively) and remained higher for 30 min compared with controls (p<0.001). Smoking increased baPWV to a greater extent in chronic smokers than in non-smokers (p<0.01). CONCLUSION: Acutely, cigarette smoking increased BP, heart rate and baPWV in chronic smokers and non-smokers. These effects were more prominent in chronic smokers than in non-smokers. These findings suggest that cigarette smoking have deleterious effects on cardiovascular system by stiffening arteries.
Jin Won Kim; Chang Gyu Park; Soon Joon Hong; Seong Mi Park; Seung Woon Rha; Hong Seog Seo; Dong Joo Oh; Young Moo Rho
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  14     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-22     Completed Date:  2005-08-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  80-5     Citation Subset:  IM    
Department of Cardiology, Korea University, Guro Hospital, Cardiovascular Center, Seoul, Korea.
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MeSH Terms
Arteries / pathology*
Blood Pressure / drug effects
Hemodynamics / physiology
Smoking / pathology*

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