| Acute and chronic effects of carbamazepine, phenytoin, valproate and vinpocetine on BAEP parameters and threshold in the guinea pig. | |
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MedLine Citation:
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PMID: 17157555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To characterize the acute and chronic effects of the antiepileptic drugs (AEDs): carbamazepine (CBZ), phenytoin (PHT), valproic acid (VPA) and vinpocetine (VPC), at doses 20, 6, 30 and 2mg/kg, respectively, on the latencies and amplitudes of the waves of brainstem auditory evoked potentials (BAEPs) elicited by a supra-threshold stimulus alongside BAEP threshold. METHODS: BAEPs elicited by a stimulus of high (100dB nHL) intensity and BAEP thresholds were obtained at 4 and 8kHz: before, after the start of treatment, and following 28 days of a daily injection of the AEDs. RESULTS: After the start of treatment BAEPs were unchanged. After the long term treatment, CBZ and PHT increased P3 and P4 wave peak latencies and reduced P4 amplitude. Chronic VPA did not modify BAEP waves, and chronic VPC reduced P3 and P4 latencies. P1 and P2 were unchanged. BAEP thresholds at 4 and 8kHz were increased by CBZ, PHT and VPA, and decreased by VPC. CONCLUSIONS: The chronic administration of several AEDs modifies BAEP waves of retro-cochlear origin. SIGNIFICANCE: Alterations in the generators of the later waves of BAEPs underlie, in most cases, the changes in hearing sensitivity produced by the long term treatment with AEDs at therapeutic relevant doses. |
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Authors:
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María Sitges; Vladimir Nekrassov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-08 |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 118 ISSN: 1388-2457 ISO Abbreviation: Clin Neurophysiol Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-09 Completed Date: 2007-03-09 Revised Date: 2008-09-10 |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 420-6 Citation Subset: IM |
Affiliation:
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Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico. sitges@biomedicas.unam.mx |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Anticonvulsants / pharmacology* Auditory Pathways / drug effects*, physiology Auditory Perception / drug effects, physiology Auditory Threshold / drug effects*, physiology Brain Stem / drug effects*, physiology Carbamazepine / pharmacology Electrophysiology Evoked Potentials, Auditory, Brain Stem / drug effects*, physiology Guinea Pigs Male Neural Conduction / drug effects, physiology Phenytoin / pharmacology Reaction Time / drug effects, physiology Valproic Acid / pharmacology Vinca Alkaloids / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Vinca Alkaloids; 298-46-4/Carbamazepine; 42971-12-0/vinpocetine; 57-41-0/Phenytoin; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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