Document Detail

Acute and chronic effects of cadmium on blood homeostasis of an estuarine crab, Chasmagnathus granulata, and the modifying effect of salinity.
MedLine Citation:
PMID:  11285463     Owner:  NLM     Status:  MEDLINE    
Whole body oxygen consumption and some hemolymph parameters such as pH, partial pressure of gases, level of ions and lactate were measured in the estuarine crab Chasmagnathus granulata after both acute (96 h) and chronic (2 weeks) exposure to cadmium at concentrations ranging from 0.4 to 6.3 mg/l. In all instances, the crabs developed hemolymph acidosis, but no respiratory (increased PCO2) or lactate increases were evident. Hemolymph levels of sodium and calcium were always increased by cadmium exposure. The chronic toxicity of cadmium was enhanced at 12 per mil salinity, even causing a significantly higher mortality in comparison with the higher salinity (30 per mil ) used. A general metabolic arrest took place at 12 per mil salinity in the crabs chronically exposed to cadmium, as indicated by decreases of oxygen consumption and PCO2, an increase of PO2, along with no changes in lactate levels. These imbalances were associated with severe necrosis and telangiectasia in the respiratory gills, probably leading to respiratory impairment and finally histotoxic hypoxia and death of the animals.
E M Rodríguez; R Bigi; D A Medesani; V S Stella; L S Greco; P A Moreno; J M Monserrat; G N Pellerano; M Ansaldo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  34     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-04     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  509-18     Citation Subset:  IM    
Departamento de Ciencias Biologicas, FCEyN, Pab. II, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina.
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MeSH Terms
Brachyura / drug effects*,  physiology
Cadmium / pharmacology*,  toxicity
Calcium / blood
Hemolymph / chemistry,  drug effects*,  metabolism
Homeostasis / drug effects*
Lactates / blood
Oxygen Consumption / drug effects
Sodium / blood
Sodium Chloride / pharmacology*
Reg. No./Substance:
0/Lactates; 7440-23-5/Sodium; 7440-43-9/Cadmium; 7440-70-2/Calcium; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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