| Acute and chronic antiarrhythmic efficacy of d-sotalol in patients with sustained ventricular tachyarrhythmias. | |
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MedLine Citation:
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PMID: 8293757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the clinical efficacy of d-sotalol, 84 patients with a history of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF), who had inducible sustained VT/VT at baseline electrophysiologic study (EPS), were investigated after intravenous (IV) d-sotalol (1.5-2.5 mg.kg-1). A total of 29 additional patients received only oral d-sotalol, (400-600 mg.day-1). Acute success of antiarrhythmic therapy was defined as suppression of inducible sustained VT/VF. The overall success rate of IV d-sotalol was 38% (32/84) after a mean of 4.3 drugs failed to suppress inducibility. A 78% success rate (31/40) was demonstrated in patients who were also assessed after oral d-sotalol. Torsade de pointes type VT was seen in one patient. After 1 year, only 16% of patients with a positive EPS had a recurrence compared to 43% of patients with a negative EPS (P < 0.05). Estimated survival rates were 95 and 88% after 1 and 2 years of follow-up, respectively. Only five of 56 patients discontinued d-sotalol therapy because of adverse effects. IV d-sotalol appears to be an effective antiarrhythmic agent. Its long-term efficacy is predictable on the basis of therapy guided by electrophysiologic testing in patients with refractory ventricular tachyarrhythmias. The efficacy of d-sotalol seems comparable to that reported for d,l-sotalol. |
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Authors:
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J Brachmann; W Schöls; T Beyer; M Montero; B Enders; W Kübler |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European heart journal Volume: 14 Suppl H ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-03-03 Completed Date: 1994-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 85-7 Citation Subset: IM |
Affiliation:
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Medical University Hospital, Department of Cardiology, Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Pacing, Artificial Female Follow-Up Studies Humans Male Middle Aged Sotalol / administration & dosage, chemistry, therapeutic use* Stereoisomerism Tachycardia, Ventricular / drug therapy*, epidemiology Time Factors Ventricular Fibrillation / drug therapy*, epidemiology |
| Chemical | |
Reg. No./Substance:
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3930-20-9/Sotalol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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