| Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. | |
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MedLine Citation:
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PMID: 12355323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Although melanin-concentrating hormone (MCH) is believed to be an important regulator of feeding behavior, both its acute and chronic effects on food intake as well as its interaction with other brain peptides involved in the control of appetite remain unclear. Therefore, the acute effects of MCH on food intake and the chronic effect of MCH on food intake and the gene expression of various hypothalamic peptides involved in the control of appetite were studied in rats. METHODS AND RESULTS: Either the acute or the continuous intraventricular infusion of MCH for 12 days stimulated feeding in both Wistar or Sprague-Dawley rats. Removal of the hypothalamus at the end of the chronic infusion studies allowed measurement of the expression of mRNAs encoding for MCH, neuropeptide Y (NPY), orexin, agouti gene-related peptide, cocaine and amphetamine-related transcript and neurotensin-neuropeptides involved in the control of appetite. Chronic intraventricular infusion of MCH activated only NPY mRNA synthesis in Sprague-Dawley rats. The increase in food intake in response to MCH in Sprague-Dawley rats did not appear to be due to the release of NPY since combination studies demonstrated consistently additive effects of the two peptides on food intake at maximum or near maximum doses. CONCLUSIONS: These results strongly suggest that MCH is an orexigenic peptide involved in the control of both short- and long term food intake in satiated rats and further indicate that the MCH pathway is a possible target for the control of food intake and obesity. |
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Authors:
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O Della-Zuana; F Presse; C Ortola; J Duhault; J L Nahon; N Levens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity Volume: 26 ISSN: 0307-0565 ISO Abbreviation: Int. J. Obes. Relat. Metab. Disord. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-30 Completed Date: 2002-12-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9313169 Medline TA: Int J Obes Relat Metab Disord Country: England |
Other Details:
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Languages: eng Pagination: 1289-95 Citation Subset: IM |
Affiliation:
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Division of Metabolic Diseases, Servier Research Institute, Suresnes, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Agouti-Related Protein Animals Body Weight Carrier Proteins / genetics DNA Primers Dose-Response Relationship, Drug Drug Administration Schedule Eating / drug effects* Gene Expression Regulation Hypothalamic Hormones / administration & dosage, metabolism, pharmacology* Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins* Male Melanins / administration & dosage, metabolism, pharmacology* Nerve Tissue Proteins / genetics Neuropeptide Y / genetics* Neuropeptides / genetics Neurotensin / genetics Pituitary Hormones / administration & dosage, metabolism, pharmacology* Polymerase Chain Reaction Proteins / genetics RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Agouti-Related Protein; 0/Carrier Proteins; 0/DNA Primers; 0/Hypothalamic Hormones; 0/Intercellular Signaling Peptides and Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Melanins; 0/Nerve Tissue Proteins; 0/Neuropeptide Y; 0/Neuropeptides; 0/Pituitary Hormones; 0/Proteins; 0/RNA, Messenger; 0/cocaine- and amphetamine-regulated transcript protein; 0/orexins; 39379-15-2/Neurotensin; 67382-96-1/melanin-concentrating hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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