Document Detail


Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats.
MedLine Citation:
PMID:  12355323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Although melanin-concentrating hormone (MCH) is believed to be an important regulator of feeding behavior, both its acute and chronic effects on food intake as well as its interaction with other brain peptides involved in the control of appetite remain unclear. Therefore, the acute effects of MCH on food intake and the chronic effect of MCH on food intake and the gene expression of various hypothalamic peptides involved in the control of appetite were studied in rats. METHODS AND RESULTS: Either the acute or the continuous intraventricular infusion of MCH for 12 days stimulated feeding in both Wistar or Sprague-Dawley rats. Removal of the hypothalamus at the end of the chronic infusion studies allowed measurement of the expression of mRNAs encoding for MCH, neuropeptide Y (NPY), orexin, agouti gene-related peptide, cocaine and amphetamine-related transcript and neurotensin-neuropeptides involved in the control of appetite. Chronic intraventricular infusion of MCH activated only NPY mRNA synthesis in Sprague-Dawley rats. The increase in food intake in response to MCH in Sprague-Dawley rats did not appear to be due to the release of NPY since combination studies demonstrated consistently additive effects of the two peptides on food intake at maximum or near maximum doses. CONCLUSIONS: These results strongly suggest that MCH is an orexigenic peptide involved in the control of both short- and long term food intake in satiated rats and further indicate that the MCH pathway is a possible target for the control of food intake and obesity.
Authors:
O Della-Zuana; F Presse; C Ortola; J Duhault; J L Nahon; N Levens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  26     ISSN:  0307-0565     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-30     Completed Date:  2002-12-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  1289-95     Citation Subset:  IM    
Affiliation:
Division of Metabolic Diseases, Servier Research Institute, Suresnes, France.
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MeSH Terms
Descriptor/Qualifier:
Agouti-Related Protein
Animals
Body Weight
Carrier Proteins / genetics
DNA Primers
Dose-Response Relationship, Drug
Drug Administration Schedule
Eating / drug effects*
Gene Expression Regulation
Hypothalamic Hormones / administration & dosage,  metabolism,  pharmacology*
Intercellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins*
Male
Melanins / administration & dosage,  metabolism,  pharmacology*
Nerve Tissue Proteins / genetics
Neuropeptide Y / genetics*
Neuropeptides / genetics
Neurotensin / genetics
Pituitary Hormones / administration & dosage,  metabolism,  pharmacology*
Polymerase Chain Reaction
Proteins / genetics
RNA, Messenger / metabolism
Rats
Rats, Sprague-Dawley
Rats, Wistar
Chemical
Reg. No./Substance:
0/Agouti-Related Protein; 0/Carrier Proteins; 0/DNA Primers; 0/Hypothalamic Hormones; 0/Intercellular Signaling Peptides and Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Melanins; 0/Nerve Tissue Proteins; 0/Neuropeptide Y; 0/Neuropeptides; 0/Pituitary Hormones; 0/Proteins; 0/RNA, Messenger; 0/cocaine- and amphetamine-regulated transcript protein; 0/orexins; 39379-15-2/Neurotensin; 67382-96-1/melanin-concentrating hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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