| Acute cholestatic hepatitis and the sudden rise of the pacing threshold 5 weeks after VVI-pacemaker implantation. | |
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MedLine Citation:
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PMID: 8077895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The patient we describe developed a cholestatic hepatitis and an unusual threshold elevation of about 425%, coincidently, 5 weeks after pacemaker implantation. Lead dislocation, myocardial infarction or metabolic disorder could be excluded as a reason for the pacemaker complication. Neither a biliary obstruction nor an infection of the liver could be found to explain the liver injury. Most probably, both disorders were caused by propafenone (450 mg day-1), withdrawal of the drug resulted in normalization of elevated enzyme and threshold levels. |
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Authors:
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R Schüppel; M Probst |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of internal medicine Volume: 236 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-09-30 Completed Date: 1994-09-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 353-6 Citation Subset: IM |
Affiliation:
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Medical Clinic, Herrsching, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Cardiac Pacing, Artificial* Cholestasis / complications, physiopathology* Electrocardiography Hepatitis / etiology, physiopathology* Humans Male Propafenone / adverse effects* Substance Withdrawal Syndrome / complications* Time Factors |
| Chemical | |
Reg. No./Substance:
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54063-53-5/Propafenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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