Document Detail

Acute cholestatic hepatitis and the sudden rise of the pacing threshold 5 weeks after VVI-pacemaker implantation.
MedLine Citation:
PMID:  8077895     Owner:  NLM     Status:  MEDLINE    
The patient we describe developed a cholestatic hepatitis and an unusual threshold elevation of about 425%, coincidently, 5 weeks after pacemaker implantation. Lead dislocation, myocardial infarction or metabolic disorder could be excluded as a reason for the pacemaker complication. Neither a biliary obstruction nor an infection of the liver could be found to explain the liver injury. Most probably, both disorders were caused by propafenone (450 mg day-1), withdrawal of the drug resulted in normalization of elevated enzyme and threshold levels.
R Schüppel; M Probst
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  236     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-30     Completed Date:  1994-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-6     Citation Subset:  IM    
Medical Clinic, Herrsching, Germany.
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MeSH Terms
Acute Disease
Cardiac Pacing, Artificial*
Cholestasis / complications,  physiopathology*
Hepatitis / etiology,  physiopathology*
Propafenone / adverse effects*
Substance Withdrawal Syndrome / complications*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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