| Acute childhood leukaemia and environmental exposure to potential sources of benzene and other hydrocarbons; a case-control study. | |
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MedLine Citation:
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PMID: 15317919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To analyse the association between potential environmental exposure to hydrocarbons and the risk of acute childhood leukaemia. METHODS: A hospital based multicentre case control study, stratified on centre, age, and sex, with 280 leukaemia cases and 285 controls was carried out. Data were collected by a standardised interview of the mothers. RESULTS: No clear association was seen between maternal occupational exposure to hydrocarbons during pregnancy and leukaemia, or between residential traffic density and leukaemia. There was an association between dwellings neighbouring a petrol station or a repair garage during childhood and the risk of childhood leukaemia (OR 4.0, 95% CI 1.5 to 10.3), with a duration trend. The association, which appeared particularly strong for acute non-lymphocytic leukaemia (OR 7.7, 95% CI 1.7 to 34.3), was not altered by adjustment for potential confounding factors. CONCLUSIONS: Results showed an association between acute childhood leukaemia and dwellings neighbouring auto repair garages and petrol stations, which are benzene emitting sources. These findings could be due to chance, although the strength of the association and the duration trend are arguments for a causal association. |
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Authors:
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C Steffen; M F Auclerc; A Auvrignon; A Baruchel; K Kebaili; A Lambilliotte; G Leverger; D Sommelet; E Vilmer; D Hémon; J Clavel |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 61 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-19 Completed Date: 2004-10-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
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Languages: eng Pagination: 773-8 Citation Subset: IM |
Affiliation:
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French National Institute of Health and Medical Research, INSERM U170, Villejuif, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzene
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toxicity Case-Control Studies Child Child, Preschool Environmental Exposure / adverse effects* Female France / epidemiology Humans Hydrocarbons / toxicity* Infant Infant, Newborn Male Maternal Exposure Odds Ratio Precursor Cell Lymphoblastic Leukemia-Lymphoma / chemically induced*, epidemiology Residence Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Hydrocarbons; 71-43-2/Benzene |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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