Document Detail

Acute childhood leukaemia and environmental exposure to potential sources of benzene and other hydrocarbons; a case-control study.
MedLine Citation:
PMID:  15317919     Owner:  NLM     Status:  MEDLINE    
AIM: To analyse the association between potential environmental exposure to hydrocarbons and the risk of acute childhood leukaemia. METHODS: A hospital based multicentre case control study, stratified on centre, age, and sex, with 280 leukaemia cases and 285 controls was carried out. Data were collected by a standardised interview of the mothers. RESULTS: No clear association was seen between maternal occupational exposure to hydrocarbons during pregnancy and leukaemia, or between residential traffic density and leukaemia. There was an association between dwellings neighbouring a petrol station or a repair garage during childhood and the risk of childhood leukaemia (OR 4.0, 95% CI 1.5 to 10.3), with a duration trend. The association, which appeared particularly strong for acute non-lymphocytic leukaemia (OR 7.7, 95% CI 1.7 to 34.3), was not altered by adjustment for potential confounding factors. CONCLUSIONS: Results showed an association between acute childhood leukaemia and dwellings neighbouring auto repair garages and petrol stations, which are benzene emitting sources. These findings could be due to chance, although the strength of the association and the duration trend are arguments for a causal association.
C Steffen; M F Auclerc; A Auvrignon; A Baruchel; K Kebaili; A Lambilliotte; G Leverger; D Sommelet; E Vilmer; D Hémon; J Clavel
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  61     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-19     Completed Date:  2004-10-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  773-8     Citation Subset:  IM    
French National Institute of Health and Medical Research, INSERM U170, Villejuif, France.
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MeSH Terms
Benzene / toxicity
Case-Control Studies
Child, Preschool
Environmental Exposure / adverse effects*
France / epidemiology
Hydrocarbons / toxicity*
Infant, Newborn
Maternal Exposure
Odds Ratio
Precursor Cell Lymphoblastic Leukemia-Lymphoma / chemically induced*,  epidemiology
Residence Characteristics
Reg. No./Substance:
0/Hydrocarbons; 71-43-2/Benzene

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