| Acute childhood cardiorenal syndrome and impact of cardiovascular morbidity on survival. | |
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MedLine Citation:
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PMID: 21647318 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Cardiorenal syndrome (CRS) clinical types, prevalence, aetiology, and acute cardiovascular morbidity impact on the outcome of acute kidney function perturbation were determined. Forty-seven of 101 (46.53%) patients with perturbed kidney function had CRS. Types 3 and 5 CRS were found in 10 and 37 patients, respectively. Type 3 CRS was due to acute glomerulonephritis (AGN; n = 7), captopril (n = 1), frusemide (n = 1), and hypovolaemia (n = 1). Malaria-associated haemoglobinuria (n = 20), septicaemia (n = 11), lupus nephritis (n = 3), tumour lysis syndrome (n = 2), and acute lymphoblastic leukaemia (n = 1) caused Type 5 CRS. The cumulative mortality in hypertensive CRS was similar to nonhypertensive CRS (51.4% versus 40.9%; P = .119). Mortality in CRS and non-CRS was similar (45.7% versus 24.5%; P = .053). Type 5 survived better than type 3 CRS (66.7% versus 12.5%; P = .001). Risk factors for mortality were Type 3 CRS (P = .001), AGN-associated CRS (P = .023), dialysis requiring CRS (P = .008), and heart failure due to causes other than anaemia (P = .003). All-cause-mortality was 34.2%. Preventive measures aimed at the preventable CRS aetiologies might be critical to reducing its prevalence. |
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Authors:
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Wasiu A Olowu |
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Publication Detail:
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Type: Journal Article Date: 2011-05-18 |
Journal Detail:
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Title: International journal of nephrology Volume: 2011 ISSN: 2090-2158 ISO Abbreviation: Int J Nephrol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-07 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101546753 Medline TA: Int J Nephrol Country: England |
Other Details:
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Languages: eng Pagination: 412495 Citation Subset: - |
Affiliation:
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Paediatric Nephrology and Hypertension Unit, Obafemi Awolowo University Teaching Hospitals Complex, PMB 5538, Ile-Ife, Osun State 234, Nigeria. |
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