Document Detail

Acute changes in muscle blood flow and concomitant muscle damage after an intramuscular administration.
MedLine Citation:
PMID:  15835746     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The intramuscular route (IM) is widely used but commonly induces injection site muscle damage. This study investigates the hemodynamic changes in an acute lesion induced by the IM administration of propylene glycol (PG) in rabbits. METHODS: Control groups received 1, 2, or 3 ml of PG (IM). Others were pretreated with pancuronium, dantrolene, indomethacin, or SR140333 and then received 2 ml of PG. The muscle blood flow (MBF) was assessed using fluorescent microspheres before and at 15, 45, 60, 90 min, 3 and 6 h after IM administration. Different areas within the muscle damage were quantified. RESULTS: Muscle contractions as well as a transient but major MBF increase were observed at the injection site. All treatments reduced hyperemia by up to 81% (dantrolene, 15 min) at 15, 45, and 90 min (p < 0.05). MBF had returned to basal values in all groups at 6 h. The central necrotic area was not modified, but peripheral damage (8.0 +/- 1.3 g) was reduced by dantrolene, indomethacin, and SR140333 (p < 0.05), but not by pancuronium. CONCLUSIONS: Muscle contraction and hyperemia are not responsible for muscle damage at the injection site, which is the multifactorial phenomenon, involving intracellular calcium and inflammation.
Pierre Jean Ferré; Eckart Thein; Isabelle Raymond-Letron; Pierre-Louis Toutain; Hervé Pierre Lefebvre
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  22     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-19     Completed Date:  2005-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
UMR 181 Physiopathologie et Toxicologie Expérimentales INRA-ENVT, Ecole Nationale Véterinaire, BP 87614, 31076 Toulouse Cedex 03, France.
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MeSH Terms
Injections, Intramuscular
Muscle Contraction / drug effects,  physiology
Muscle, Skeletal / blood supply*,  drug effects*,  physiology
Propylene Glycol / administration & dosage*
Regional Blood Flow / drug effects,  physiology
Reg. No./Substance:
57-55-6/Propylene Glycol

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