Document Detail


Acute changes in left ventricular diastolic function: cigarette smoking versus nicotine gum.
MedLine Citation:
PMID:  16506640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Echocardiographic evidence of diastolic dysfunction has been demonstrated during acute cigarette smoking in patients with coronary artery disease. Similar studies in healthy patients have shown conflicting results. Furthermore, it is unclear whether nicotine or some other cigarette-related substance is responsible for these observations. HYPOTHESIS: The purpose of the study was to confirm or refute acute effects of cigarette smoking on diastolic function in healthy patients and to compare diastolic effects of a cigarette to smokeless nicotine delivery (nicotine gum). METHODS: In all, 27 healthy volunteers were self-assigned into one of two cohorts. A baseline echocardiogram was performed in all patients. The first cohort proceeded to smoke a cigarette and the second to chew a piece of nicotine gum. Within minutes after exposure, another echocardiogram was performed. Traditional measures of diastolic function were compared before and after substance exposure by paired t-tests. RESULTS: The cigarette cohort showed echocardiographic evidence of diastolic dysfunction after smoking. The E:A ratio (time integral) decreased from 2.95 to 2.22 (p < 0.002). Atrial reversal pulmonary velocity, atrial reversal duration, and color flow propagation all showed statistically significant alterations (p < 0.05). The nicotine gum cohort showed no change in traditional diastolic parameters. CONCLUSIONS: Diastolic function is impaired during acute exposure to cigarette smoke but unchanged after exposure to nicotine gum. It is therefore unlikely that nicotine alone is responsible for cigarette-induced acute diastolic dysfunction.
Authors:
Mathew I Gembala; Firas Ghanem; Christopher A Mann; Vincent L Sorrell
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  29     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-01     Completed Date:  2007-07-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
Affiliation:
University of Arizona, Tucson, Arizona 85724-5037, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chewing Gum
Cohort Studies
Coronary Artery Disease / physiopathology*
Diastole / drug effects,  physiology
Echocardiography, Doppler
Female
Humans
Male
Nicotine / administration & dosage,  adverse effects,  pharmacology*
Smoking*
Ventricular Function, Left / drug effects*
Chemical
Reg. No./Substance:
0/Chewing Gum; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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