| Acute changes in carbon dioxide levels alter the electroencephalogram without affecting cognitive function. | |
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MedLine Citation:
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PMID: 10934900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The partial pressure of carbon dioxide in the arterial blood (PaCO2) is usually tightly regulated, yet it varies among healthy people at rest (range approximately 32-44 mmHg) as well as within an individual during many natural life situations. The present study examined whether modest changes in end-tidal PCO2 (PETCO2; a noninvasive measure of PaCO2) affect electroencephalographic (EEG) activity, cognitive function, and vigilance. Nine adults were ventilated mechanically using a mouthpiece; respiratory rate and breath size were held constant while PETCO2 was set to levels that produced minimal discomfort. Despite discrete changes in EEG, neither acute PETCO2 increases (mean = 47 mmHg) nor decreases (mean = 30 mmHg) from resting levels (mean = 38 mmHg) affected performance on cognitive tasks, latency or amplitude of the N1, P2, or P3 event-related potential, or alertness. Modest changes in PETCO2 may cause significant alterations in the EEG without disturbing cognitive function. |
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Authors:
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E Bloch-Salisbury; R Lansing; S A Shea |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychophysiology Volume: 37 ISSN: 0048-5772 ISO Abbreviation: Psychophysiology Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-08-29 Completed Date: 2000-08-29 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0142657 Medline TA: Psychophysiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 418-26 Citation Subset: IM |
Affiliation:
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Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA. ebsalis@hsph.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alpha Rhythm / drug effects Arousal / drug effects Blood Pressure / drug effects Carbon Dioxide / pharmacology* Cognition / drug effects* Electroencephalography / drug effects* Evoked Potentials, Auditory / drug effects Female Fourier Analysis Heart Rate / drug effects Humans Male Psychomotor Performance / drug effects Respiration, Artificial |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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