| Acute changes in blood glucose affect resistance to ischemic nerve conduction failure. | |
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MedLine Citation:
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PMID: 2296356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied resistance to ischemic nerve conduction failure (RINCF) following rapid alterations of blood glucose in normal and diabetic rats. We measured RINCF hourly for 4 hours in normal and diabetic rats. We then made normal rats hyperglycemic and diabetics euglycemic. In normal rats, we measured RINCF sequentially for 4 hours immediately after glucose injection and once after 1, 2, 3, or 4 hours of hyperglycemia. In diabetics, we measured RINCF sequentially for 4 hours after insulin injection. In normal rats, in sequential measurements, RINCF progressively fell but glucose injection prevented this fall. Hyperglycemia without preceding ischemia increased RINCF. In diabetic rats, sequential measurements also produced a decline in RINCF, accentuated with insulin injection. The results suggest that both glucose and insulin are important in determining the response of peripheral nerve to ischemia. They also underscore the importance of knowing the blood glucose and time of most recent insulin injection when measuring RINCF. |
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Authors:
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G J Parry; H Kohzu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 40 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-16 Completed Date: 1990-02-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 107-10 Citation Subset: AIM; IM |
Affiliation:
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LSU School of Medicine, Department of Neurology, New Orleans 70112. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / physiology* Diabetes Mellitus, Experimental / physiopathology* Diabetes Mellitus, Type 1 / physiopathology* Hyperglycemia / physiopathology Ischemia / physiopathology* Neural Conduction* Peripheral Nerves / blood supply* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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