Document Detail

Acute cervical segmental denervation in neuromyelitis optica spectrum disorder.
MedLine Citation:
PMID:  25415521     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of central nervous system. We report a case of NMO spectrum disorder that developed acute cervical segmental denervation during an episode of transverse myelitis.
METHODS: Case report and a literature review.
RESULTS: A 69-year-old woman presented with right leg weakness, which improved in 2 weeks of intravenous methylprednisolone. Six weeks later, she returned with recurrent transverse myelitis followed by left hand weakness and atrophy. Electromyography showed active denervation on left C8/T1-innervated muscles. Magnetic resonance imaging of thoracic spine showed patchy T2-signal enhancement from T10 to lower cervical spine. NMO antibody was positive. Review of literature revealed 5 cases of cervical transverse myelitis that developed denervation on electromyography.
CONCLUSIONS: Segmental denervation may occur in NMO and variants resulting from severe myelitis extending to involve gray and white matter leads to anterior horn cell loss.
Prompan Mingbunjerdsuk; Bashar Katirji
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuromuscular disease     Volume:  16     ISSN:  1537-1611     ISO Abbreviation:  J Clin Neuromuscul Dis     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887391     Medline TA:  J Clin Neuromuscul Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-7     Citation Subset:  IM    
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