| Acute carotid artery occlusive thrombosis and its pharmacological prevention in the rabbit. | |
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MedLine Citation:
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PMID: 1866710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simple and reproducible method to induce an occlusive thrombus in rabbit carotid artery is reported. Rabbits were anesthetized and prepared to record arterial pressure, heart rate, and carotid blood flow. A critical stenosis of a damaged carotid artery was obtained using an external plastic cylinder. Complete occlusion occurred within 6 to 12 minutes, as measured by the decrease in blood flow. Both stenosis of the vessel and deliberate damage (clamping by surgical forceps) were found essential to occlusion. Occlusion was prevented by administration of heparin (200 IU/kg), tissue plasminogen activator (300 micrograms/kg), iloprost (10 micrograms/kg) or the synthetic thrombin inhibitor, FPRCH2Cl (0.5 mg/kg), while ASA (100 mg/kg) was uneffective. The procedure permits an easy and rapid evaluation of thrombus formation and of anti-thrombotic drugs affecting the hemostatic process. |
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Authors:
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C Bevilacqua; M Finesso; M Prosdocimi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thrombosis research Volume: 62 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-09-10 Completed Date: 1991-09-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 263-73 Citation Subset: IM |
Affiliation:
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Fidia Research Laboratories, Abano Terme, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Arterial Occlusive Diseases / prevention & control* Carotid Artery Thrombosis / prevention & control* Disease Models, Animal Fibrinolytic Agents / therapeutic use* Heparin / therapeutic use* Male Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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