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Acute cardiovascular responses in preterm infants at 34-39weeks of gestational age.
MedLine Citation:
PMID:  22831637     Owner:  NLM     Status:  Publisher    
BACKGROUND: Premature infants demonstrate immature physiological control mechanisms; however their acute cardiovascular control has not yet been widely studied. AIM: The aim of this study was to analyze heart rate (HR) and blood pressure (BP) control in preterm infants. SUBJECTS: Twenty preterm infants with a mean gestational age of 31±2.4 (26-34) weeks at birth were evaluated at a gestational age of 36±1.5 (34-39) weeks. Results were compared to twenty, healthy, full-term, control infants studied at the age of 12±3weeks. OUTCOME MEASURES: HR and BP responses to 45° head-up tilt and side motion tests during non-rapid eye movement sleep were analyzed. In addition, HR responses to spontaneous arousals from non-rapid eye movement sleep were evaluated. RESULTS: Preterm infants showed significantly smaller initial HR and BP responses compared with controls in head-up tilt (HR p=0.0005, systolic BP p=0.02, diastolic BP p=0.01) and side motion tests (HR p=0.002, systolic BP p<0.0001, diastolic BP p<0.0001). Furthermore, in tilt tests, preterm infants presented with greater intersubject variability in BP responses than controls (systolic BP p=0.009, diastolic BP p=0005). Preterm HR responses to spontaneous arousals were similar to controls. CONCLUSIONS: This study indicates immature vestibulo-mediated cardiovascular control in preterm infants compared with term infants. This is seen as attenuated BP responses to side motion test and more labile acute BP control to postural challenge.
Suvi Viskari-Lähdeoja; Timo Hytinantti; Sture Andersson; Turkka Kirjavainen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-23
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Children's Hospital, University of Helsinki and Helsinki University Central Hospital, 00029 HUS, Finland; Department of Ophthalmology, University of Helsinki and Helsinki University Central Hospital, 00029 HUS, Finland.
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