| Acute cardiovascular responses in preterm infants at 34-39weeks of gestational age. | |
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MedLine Citation:
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PMID: 22831637 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Premature infants demonstrate immature physiological control mechanisms; however their acute cardiovascular control has not yet been widely studied. AIM: The aim of this study was to analyze heart rate (HR) and blood pressure (BP) control in preterm infants. SUBJECTS: Twenty preterm infants with a mean gestational age of 31±2.4 (26-34) weeks at birth were evaluated at a gestational age of 36±1.5 (34-39) weeks. Results were compared to twenty, healthy, full-term, control infants studied at the age of 12±3weeks. OUTCOME MEASURES: HR and BP responses to 45° head-up tilt and side motion tests during non-rapid eye movement sleep were analyzed. In addition, HR responses to spontaneous arousals from non-rapid eye movement sleep were evaluated. RESULTS: Preterm infants showed significantly smaller initial HR and BP responses compared with controls in head-up tilt (HR p=0.0005, systolic BP p=0.02, diastolic BP p=0.01) and side motion tests (HR p=0.002, systolic BP p<0.0001, diastolic BP p<0.0001). Furthermore, in tilt tests, preterm infants presented with greater intersubject variability in BP responses than controls (systolic BP p=0.009, diastolic BP p=0005). Preterm HR responses to spontaneous arousals were similar to controls. CONCLUSIONS: This study indicates immature vestibulo-mediated cardiovascular control in preterm infants compared with term infants. This is seen as attenuated BP responses to side motion test and more labile acute BP control to postural challenge. |
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Authors:
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Suvi Viskari-Lähdeoja; Timo Hytinantti; Sture Andersson; Turkka Kirjavainen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-23 |
Journal Detail:
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Title: Early human development Volume: - ISSN: 1872-6232 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Children's Hospital, University of Helsinki and Helsinki University Central Hospital, 00029 HUS, Finland; Department of Ophthalmology, University of Helsinki and Helsinki University Central Hospital, 00029 HUS, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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