Document Detail

Acute cardiovascular response to a single large intravenous dose of methylprednisolone and its effects on the responses to norepinephrine and isoproterenol.
MedLine Citation:
PMID:  6867008     Owner:  NLM     Status:  MEDLINE    
The cardiovascular actions of single 10-micrograms/kg iv doses of norepinephrine (NE) and isoproteronol (ISO), before and after the administration of a single 30-mg/kg iv dose of the glucocorticoid methylprednisolone (MP) (sodium succinate ester), were compared in adult cats. Methylprednisolone increased both systolic and diastolic pressures as well as the pulse pressure by approximately 50%. These steroid effects persisted unabated for the duration of the experiment (40 min). Heart rate was unaffected by MP. MP treatment significantly reduced the increase in systolic and diastolic pressures caused by NE. This MP effect was unrelated to the higher baselines for these two parameters caused by the steroid. The systolic blood pressure and positive chronotropic effects of ISO were also significantly blunted by MP. These observations suggest that a single large dose of MP may cause a depression of cardiovascular alpha- and beta-1-receptor sensitivity. The results are discussed in relation to the actions of massive dose glucocorticoid administration in certain shock states and central nervous system trauma and stroke.
E D Hall; M Plaster; J M Braughler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  173     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  338-43     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Isoproterenol / pharmacology*
Methylprednisolone / administration & dosage,  pharmacology*
Norepinephrine / pharmacology*
Reg. No./Substance:
51-41-2/Norepinephrine; 7683-59-2/Isoproterenol; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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