Document Detail

Acute cardiovascular response in anabolic androgenic steroid users performing maximal treadmill exercise testing.
MedLine Citation:
PMID:  20508475     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the cardiovascular effects of anabolic androgenic steroid (AAS) use, specifically the hemodynamic response, during maximal treadmill exercise testing by comparing the exercise response between users of AAS (U-AAS) and non-AAS users (N-AAS). Twenty-four men (n=12; 29+/-3.4 years and n=12; 29.5+/-8.2 years for the U-AAS and N-AAS groups, respectively) with regular participation in both resistance (mean=6 d.wk) and aerobic exercise (mean=2 d.wk) volunteered for the study. Both groups of subjects completed a ramp-protocol maximal treadmill exercise test to volitional fatigue. Several hemodynamic and metabolic measures were obtained before, during, and after testing. The results demonstrate for the first time that chronic administration of high doses of AAS (355.4+/-59.47 mg.wk) lead to hemodynamic and metabolic response impairment. In conclusion, the chronotropic significant incompetence in the current study was reflected by an exaggerated hemodynamic response to exercise. Furthermore, the findings suggest that nonusers of AAS showed increases in VO2max when compared to the AAS group. Therefore, this study provides a contraindication to AAS use, especially in those at increased risk of cardiovascular events.
Alex S Maior; Roberto Simão; Belmiro Freitas de Salles; Jeffrey L Alexander; Matthew Rhea; José H M Nascimento
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of strength and conditioning research / National Strength & Conditioning Association     Volume:  24     ISSN:  1533-4287     ISO Abbreviation:  J Strength Cond Res     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9415084     Medline TA:  J Strength Cond Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1688-95     Citation Subset:  IM    
Federal University of Rio de Janeiro, Institute of Biophysics Carlos Chagas Filho (IBCCF/UFRJ), Rio de Janeiro, Brazil.
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MeSH Terms
Anabolic Agents / administration & dosage,  adverse effects*,  contraindications
Androgens / administration & dosage,  adverse effects*,  contraindications
Cardiovascular Diseases / chemically induced
Exercise Test
Hemodynamics / drug effects*
Oxygen Consumption / drug effects
Resistance Training
Testosterone / analogs & derivatives*
Reg. No./Substance:
0/Anabolic Agents; 0/Androgens; 58-22-0/Testosterone
Erratum In:
J Strength Cond Res. 2010 Jul;24(7):1974

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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