| Acute cardiovascular response in anabolic androgenic steroid users performing maximal treadmill exercise testing. | |
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MedLine Citation:
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PMID: 20508475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the cardiovascular effects of anabolic androgenic steroid (AAS) use, specifically the hemodynamic response, during maximal treadmill exercise testing by comparing the exercise response between users of AAS (U-AAS) and non-AAS users (N-AAS). Twenty-four men (n=12; 29+/-3.4 years and n=12; 29.5+/-8.2 years for the U-AAS and N-AAS groups, respectively) with regular participation in both resistance (mean=6 d.wk) and aerobic exercise (mean=2 d.wk) volunteered for the study. Both groups of subjects completed a ramp-protocol maximal treadmill exercise test to volitional fatigue. Several hemodynamic and metabolic measures were obtained before, during, and after testing. The results demonstrate for the first time that chronic administration of high doses of AAS (355.4+/-59.47 mg.wk) lead to hemodynamic and metabolic response impairment. In conclusion, the chronotropic significant incompetence in the current study was reflected by an exaggerated hemodynamic response to exercise. Furthermore, the findings suggest that nonusers of AAS showed increases in VO2max when compared to the AAS group. Therefore, this study provides a contraindication to AAS use, especially in those at increased risk of cardiovascular events. |
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Authors:
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Alex S Maior; Roberto Simão; Belmiro Freitas de Salles; Jeffrey L Alexander; Matthew Rhea; José H M Nascimento |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of strength and conditioning research / National Strength & Conditioning Association Volume: 24 ISSN: 1533-4287 ISO Abbreviation: J Strength Cond Res Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9415084 Medline TA: J Strength Cond Res Country: United States |
Other Details:
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Languages: eng Pagination: 1688-95 Citation Subset: IM |
Affiliation:
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Federal University of Rio de Janeiro, Institute of Biophysics Carlos Chagas Filho (IBCCF/UFRJ), Rio de Janeiro, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anabolic Agents / administration & dosage, adverse effects*, contraindications Androgens / administration & dosage, adverse effects*, contraindications Cardiovascular Diseases / chemically induced Exercise* Exercise Test Hemodynamics / drug effects* Humans Male Oxygen Consumption / drug effects Resistance Training Testosterone / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Androgens; 58-22-0/Testosterone |
| Comments/Corrections | |
Erratum In:
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J Strength Cond Res. 2010 Jul;24(7):1974 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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