| Acute cardiac toxicity of antineoplastic agents as the first manifestation of pheochromocytoma. | |
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MedLine Citation:
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PMID: 361218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 47-year-old male with histiocytic lymphoma and no previous history of heart disease developed significant fluctuations of blood pressure, electrocardiographic evidence of myocardial ischemia, and life-threatening arrhythmia after the first dose of BACOP (bleomycin, adriamycin, cyclophosphamide, Oncovin, and prednisone) chemotherapy. The presence of pheochromocytoma was suspected, and it was demonstrated by elevated urinary metanephrines, catecholamines, and vanillylmandelic acid, and finally confirmed on autopsy. The possible role of chemotherapeutic agents in stimulating excessive catecholamine release, thus causing transient cardiac injury, is suggested. |
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Authors:
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D N DeAsis; M K Ali; A Soto; N A Samaan |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer Volume: 42 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1978 Oct |
Date Detail:
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Created Date: 1979-01-15 Completed Date: 1979-01-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2005-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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diagnosis*,
secretion Antineoplastic Agents / adverse effects* Arrhythmias, Cardiac / etiology* Catecholamines / secretion Coronary Disease / etiology* Humans Lymphoma, Large B-Cell, Diffuse / drug therapy* Male Middle Aged Neoplasms, Multiple Primary / diagnosis*, secretion Pheochromocytoma / diagnosis*, secretion |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Catecholamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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