| Acute cardiac tolerance of current contrast media and the new taxane protaxel using iopromide as carrier during porcine coronary angiography and stenting. | |
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MedLine Citation:
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PMID: 11753151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: The systemic tolerance thresholds of modern low-osmolar x-ray contrast media (CM) are similarly high, but their effects on the cardiovascular system and on the coagulation differ. The aim of this study was to comparatively evaluate the cardiovascular tolerability of iopromide, ioxaglate, and iosmin, and of a novel taxane protaxel, dissolved in iopromide, as a carrier, by coronary angiography and stenting. METHODS: Sixteen pigs were randomized into four groups: iosmin (350 mg iodine/mL, n = 4, nonionic dimer), iopromide (370 mg iodine/mL, n = 4, nonionic monomer), ioxaglate (320 mg iodine/mL, n = 4, ionic dimer), and 70-micromol protaxel dissolved in iopromide 370 mg iodine/mL, intended to prevent restenosis. Coronary angiography was performed via the left carotid artery followed by implantation of stents into the left anterior descending and the circumflex arteries. About 80 mL per animal was used in each group. RESULTS: There were no thrombotic complications and no significant adverse events of electrocardiography, blood pressure, or contractility during or after CM injections. There were no differences among the CM tested except that ioxaglate was the only agent showing a significant reduction in dp/dt after 50 seconds compared to iosmin. The values of preinjection parameters were most rapidly regained after iosmin, compared with other CM tested. CONCLUSIONS: The novel iso-osmolar nonionic CM iosmin is well tolerated in porcine coronary angiography and subsequent stenting. The cardiac tolerance of iopromide has not been adversely affected by addition of the cytostatic protaxel. |
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Authors:
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Bruno Scheller; Ulrich Speck; Alexander Schmitt; Wolfam Clauss; Milos Sovak; Michael Böhm; Hans Peter Stoll |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 37 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2001-12-25 Completed Date: 2002-03-25 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 29-34 Citation Subset: IM |
Affiliation:
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Internal Medicine III (Cardiology), University of Saarland, Homburg/Saar, Germany. scheller@med-in.uni-saarland.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzamides* Contrast Media* / adverse effects Coronary Angiography / methods* Iodine / adverse effects, diagnostic use Iohexol / adverse effects, analogs & derivatives*, diagnostic use Ioxaglic Acid / adverse effects, diagnostic use Models, Animal Paclitaxel / adverse effects, analogs & derivatives*, diagnostic use Prodrugs / diagnostic use Propanolamines* Stents Swine Taxoids* |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/Contrast Media; 0/Prodrugs; 0/Propanolamines; 0/Taxoids; 0/iosmin; 0/protaxel; 33069-62-4/Paclitaxel; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol; 73334-07-3/iopromide; 7553-56-2/Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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