Document Detail


Acute cardiac events temporally related to cocaine abuse.
MedLine Citation:
PMID:  3785295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increasingly widespread use of cocaine in the United States has been accompanied and perhaps exacerbated by the misconception that the drug is not associated with serious medical complications. In particular, the potential for cocaine to precipitate life-threatening cardiac events needs to be reemphasized. We report the clinical and pathological findings in seven people in whom nonintravenous "recreational" use of cocaine was temporally related to acute myocardial infarction, ventricular tachycardia and fibrillation, myocarditis, sudden death, or a combination of these events. We also review data on 19 previously reported cases of cocaine-related cardiovascular disorders. Analysis of all 26 patients indicated the following findings: the cardiac consequences of cocaine abuse are not unique to parenteral use of the drug, since nearly all the patients took the drug intranasally; underlying heart disease is not a prerequisite for cocaine-related cardiac disorders; seizure activity, a well-documented noncardiac complication of cocaine abuse, is neither a prerequisite for, nor an accompanying feature of, cardiac toxicity of cocaine; and the cardiac consequences of cocaine are not limited to massive doses of the drug. Although the pathogenesis of cardiac toxicity of cocaine remains incompletely defined, available circumstantial evidence suggests that cocaine has medical consequences that are equal in importance to its well-documented psychosocial consequences.
Authors:
J M Isner; N A Estes; P D Thompson; M R Costanzo-Nordin; R Subramanian; G Miller; G Katsas; K Sweeney; W Q Sturner
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  315     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1986-12-23     Completed Date:  1986-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1438-43     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Administration, Intranasal
Adult
Cocaine / administration & dosage,  adverse effects*
Death, Sudden
Female
Heart / drug effects
Heart Diseases / chemically induced*
Humans
Male
Myocardial Infarction / chemically induced
Myocarditis / chemically induced
Substance-Related Disorders / complications*
Tachycardia / chemically induced
Ventricular Fibrillation / chemically induced
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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