Document Detail


Acute carbon dioxide avoidance in Caenorhabditis elegans.
MedLine Citation:
PMID:  18524955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carbon dioxide is produced as a by-product of cellular respiration by all aerobic organisms and thus serves for many animals as an important indicator of food, mates, and predators. However, whether free-living terrestrial nematodes such as Caenorhabditis elegans respond to CO2 was unclear. We have demonstrated that adult C. elegans display an acute avoidance response upon exposure to CO2 that is characterized by the cessation of forward movement and the rapid initiation of backward movement. This response is mediated by a cGMP signaling pathway that includes the cGMP-gated heteromeric channel TAX-2/TAX-4. CO2 avoidance is modulated by multiple signaling molecules, including the neuropeptide Y receptor NPR-1 and the calcineurin subunits TAX-6 and CNB-1. Nutritional status also modulates CO2 responsiveness via the insulin and TGFbeta signaling pathways. CO2 response is mediated by a neural circuit that includes the BAG neurons, a pair of sensory neurons of previously unknown function. TAX-2/TAX-4 function in the BAG neurons to mediate acute CO2 avoidance. Our results demonstrate that C. elegans senses and responds to CO2 using multiple signaling pathways and a neural network that includes the BAG neurons and that this response is modulated by the physiological state of the worm.
Authors:
Elissa A Hallem; Paul W Sternberg
Related Documents :
21154995 - Quorum sensing in bacterial species that use degenerate autoinducers can be tuned by us...
10945225 - Dap12 and kap10 (dap10)-novel transmembrane adapter proteins of the cd3zeta family.
8755475 - Numb antagonizes notch signaling to specify sibling neuron cell fates.
22106175 - Redefining the classification of ampa-selective ionotropic glutamate receptors.
9078685 - Clinical significance of igg fc receptors and fc gamma r-directed immunotherapies.
8866355 - Increased neuronal excitability during depolarization-induced suppression of inhibition...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-04
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  105     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-11     Completed Date:  2008-06-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8038-43     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. ehallem@caltech.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / drug effects*
Caenorhabditis elegans / drug effects*,  physiology*
Carbon Dioxide / pharmacology*
Cyclic GMP / metabolism
Food Deprivation
Insulin / metabolism
Nerve Net / drug effects,  metabolism
Neurons / drug effects,  metabolism
Receptors, Neuropeptide Y / metabolism
Signal Transduction / drug effects
Species Specificity
Transforming Growth Factor beta / metabolism
Grant Support
ID/Acronym/Agency:
//Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Receptors, Neuropeptide Y; 0/Transforming Growth Factor beta; 11061-68-0/Insulin; 124-38-9/Carbon Dioxide; 7665-99-8/Cyclic GMP
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caeno...
Next Document:  Historical contingency and the evolution of a key innovation in an experimental population of Escher...