Document Detail


Acute calcium entry blockade inhibits the blood pressure but not the hormonal responses to angiotensin II.
MedLine Citation:
PMID:  2550243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of acute calcium entry blockade by isradipine (IS) and placebo (P) on the haemodynamic and humoral responses to angiotensin II (A II) have been compared in two groups of 9 patients with essential hypertension. During 4 sequential periods each of 20 min, an i.v. infusion of A II 0, 2, 4 and 8 ng.kg-1.min-1 was given before (control) and 30 min after the oral administration either of IS or P. After IS, both the blood pressure and the angiotensin II-induced pressor effect were significantly reduced. Isradipine increased the heart rate and this cardio-acceleration was potentiated by A II. In contrast, when A II was infused in the absence of IS, heart rate tended to decrease. IS stimulated plasma renin activity and reduced plasma aldosterone. However, it did not affect either the inhibition of plasma renin activity or the rise in plasma aldosterone in response to A II. In conclusion, acute calcium entry blockade in patients with essential hypertension reduces the pressor response to A II, but not the A II-induced inhibition of renin and increase in plasma aldosterone.
Authors:
J Staessen; R Fagard; P Hespel; P Lijnen; E Moerman; A Amery
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  36     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-10-19     Completed Date:  1989-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  567-73     Citation Subset:  IM    
Affiliation:
Department of Pathophysiology, University of Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Aldosterone / blood
Angiotensin II / antagonists & inhibitors,  pharmacology*
Blood Pressure / drug effects*
Calcium Channel Blockers / pharmacology*
Heart Rate / drug effects
Humans
Hydrocortisone / blood
Hypertension / physiopathology*
Isradipine
Middle Aged
Norepinephrine / blood
Pyridines / pharmacology*
Renin / blood
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Pyridines; 11128-99-7/Angiotensin II; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 52-39-1/Aldosterone; 75695-93-1/Isradipine; 9002-60-2/Adrenocorticotropic Hormone; EC 3.4.23.15/Renin

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