Document Detail


Acute blood toxicity of the abused inhalant, cyclohexyl nitrite.
MedLine Citation:
PMID:  9439769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cyclohexyl nitrite is an abused nitrite inhalant. This is the first report of toxicity of cyclohexyl nitrite. Mice were exposed to 300-900 ppm cyclohexyl nitrite in an inhalation chamber for 45 min and then bled. Such treatment resulted in a 7-10% reduction in red blood cell counts, haemoglobin and haematocrit levels. Both blood leucocyte counts and spleen cellularity were reduced by 40%. Unlike isobutyl nitrite, subchronic treatment of mice with cyclohexyl nitrite did not impair macrophage tumoricidal activity or production of reactive nitrogen intermediates, but did modulate B and T cell mitogen responses. The data suggest that cyclohexyl nitrite had cytotoxic activity, comparable to that of isobutyl nitrite, which might be related to the anaemia reported in abusers. The immunomodulatory properties of cyclohexyl nitrite differed from those of isobutyl nitrite.
Authors:
L S Soderberg; J T Flick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of immunopharmacology     Volume:  19     ISSN:  0192-0561     ISO Abbreviation:  Int. J. Immunopharmacol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1998-02-26     Completed Date:  1998-02-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7904799     Medline TA:  Int J Immunopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Blood Cell Count / drug effects*
Lymphocytes / drug effects
Macrophages / drug effects
Mice
Nitrites / administration & dosage,  toxicity*
Street Drugs*
Vasodilator Agents / administration & dosage,  toxicity*
Grant Support
ID/Acronym/Agency:
DA06662/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Nitrites; 0/Street Drugs; 0/Vasodilator Agents; 0/cyclohexyl nitrite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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