Document Detail


Acute blood pressure elevation and ventricular fibrillation threshold during coronary occlusion and reperfusion in the dog.
MedLine Citation:
PMID:  848436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of acute elevation of arterial blood pressure on the ventricular fibrillation threshold was examined in 19 closed chest dogs anesthetized with chloralose during 10 minutes of occlusion followed by abrupt reperfusion of the left anterior descending coronary artery. Ventricular fibrillation threshold was determined using two methods of electrical testing: sequential R/T pulsing and the train of stimuli method. Blood pressure was increased with an intravenous injection of the alpha adrenergic stimulator phenylephrine. Acute hypertension significantly diminished the enhanced vulnerability associated with coronary occlusion. After denervation of the carotid sinus and aortic arch baroreceptors, elevation of blood pressure failed to affect vulnerability during occlusion. In both intact and denervated animals, the predisposition to ventricular fibrillation after reperfusion was unchanged by the increase in blood pressure. It is suggested that withdrawal of sympathetic tone mediated by the baroreceptor reflex is the basis for the protection against ventricular fibrillation resulting from elevation of blood pressure. The failure of acute hypertension to alter vulnerability during reperfusion suggests that the predisposition to ventricular fibrillation during reperfusion is due to mechanisms other than those operating during coronary occlusion.
Authors:
C M Blatt; R L Verrier; B Lown
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  39     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-05-20     Completed Date:  1977-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  523-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / innervation
Blood Pressure* / drug effects
Carotid Sinus / innervation
Coronary Circulation
Coronary Disease / complications*
Coronary Vessels / surgery
Denervation
Disease Models, Animal
Dogs
Ligation
Phenylephrine / pharmacology
Ventricular Fibrillation / etiology*
Chemical
Reg. No./Substance:
59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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