Document Detail


Acute behavioral effects of intrapleural OK-432 (Picibanil) administration in preterm fetal sheep.
MedLine Citation:
PMID:  19776593     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To develop a model to study the fetal effects of intrapleural infusion of OK-432 (Picibanil), a pleurodesis agent derived from killed Gram-positive streptococci. METHODS: OK-432 (0.1 mg, n = 5), or normal saline (n = 5) were infused over 20 min into the pleural space of chronically instrumented preterm fetal sheep at 0.7 gestation. Fetal physiological parameters, including breathing and nuchal activity were monitored in utero from 6 h before infusion until 12 h afterward, and fetuses were killed after 7 days recovery. RESULTS: OK-432 was associated with transient suppression of fetal EEG activity, breathing and body movements from 3-6 h after infusion. Hypotension and hypoxia did not occur. At postmortem, local pleural adhesions were seen around the site of OK-432 infusion but not in saline treated fetuses. CONCLUSIONS: Intrapleural administration of OK-432 is associated with marked but transient fetal behavioral effects. This model will enable preclinical investigation of the neural and cardiovascular safety of OK-432 at a clinical relevant stage of development.
Authors:
Rosalind V Cowie; Peter R Stone; Emma Parry; Ellen C Jensen; Alistair J Gunn; Laura Bennet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-22
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  25     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-24     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  304-13     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Department of Physiology, University of Auckland, Auckland 1023, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Chylothorax / drug therapy,  veterinary
Fetus / drug effects*
Heart Rate, Fetal / drug effects
Picibanil / administration & dosage,  adverse effects*
Pleural Cavity / drug effects,  pathology
Respiration / drug effects
Sheep / physiology*
Chemical
Reg. No./Substance:
39325-01-4/Picibanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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