| Acute behavioral and cardiac effects of cocaine and alcohol combinations in humans. | |
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MedLine Citation:
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PMID: 7870965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subjects received acute doses of orally administered alcohol (0-1.0 g/kg) and intranasal cocaine (4-96 mg/70 kg) alone and in combination in two experiments. Results generally were consistent across both experiments. Cocaine administered alone improved Digit Symbol Substitution Test (DSST) performance, increased subject ratings of stimulant-like effects, heart rate and blood pressure, and decreased skin temperature. Alcohol administered alone disrupted DSST performance, increased ratings of drunkenness, heart rate and skin temperature, and decreased blood pressure. Combining cocaine and alcohol attenuated the disruptions in DSST performance observed with alcohol alone, and either did not change or attenuated the improvements in performance observed with cocaine alone. Combining the drugs also attenuated effects observed with the drugs alone on skin temperature and, to a lesser extent, blood pressure. By contrast, drug combinations increased heart rate above levels observed when cocaine or alcohol were administered alone. Effects of the drug combinations on subject ratings were variable. |
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Authors:
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S T Higgins; C R Rush; W K Bickel; J R Hughes; M Lynn; M A Capeless |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychopharmacology Volume: 111 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1993 |
Date Detail:
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Created Date: 1995-03-28 Completed Date: 1995-03-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 285-94 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Vermont, Burlington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Administration, Oral Adult Affect / drug effects Behavior / drug effects* Blood Pressure / drug effects Cocaine / administration & dosage, pharmacology* Dextroamphetamine / pharmacology Dose-Response Relationship, Drug Double-Blind Method Drug Interactions Ethanol / administration & dosage, pharmacology* Euphoria / drug effects Female Heart / drug effects* Heart Rate / drug effects Humans Male Psychomotor Performance / drug effects Skin Temperature / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DA-04545/DA/NIDA NIH HHS; DA-05382/DA/NIDA NIH HHS; DA-05538/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 51-64-9/Dextroamphetamine; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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