Document Detail


Acute behavioral and cardiac effects of cocaine and alcohol combinations in humans.
MedLine Citation:
PMID:  7870965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Subjects received acute doses of orally administered alcohol (0-1.0 g/kg) and intranasal cocaine (4-96 mg/70 kg) alone and in combination in two experiments. Results generally were consistent across both experiments. Cocaine administered alone improved Digit Symbol Substitution Test (DSST) performance, increased subject ratings of stimulant-like effects, heart rate and blood pressure, and decreased skin temperature. Alcohol administered alone disrupted DSST performance, increased ratings of drunkenness, heart rate and skin temperature, and decreased blood pressure. Combining cocaine and alcohol attenuated the disruptions in DSST performance observed with alcohol alone, and either did not change or attenuated the improvements in performance observed with cocaine alone. Combining the drugs also attenuated effects observed with the drugs alone on skin temperature and, to a lesser extent, blood pressure. By contrast, drug combinations increased heart rate above levels observed when cocaine or alcohol were administered alone. Effects of the drug combinations on subject ratings were variable.
Authors:
S T Higgins; C R Rush; W K Bickel; J R Hughes; M Lynn; M A Capeless
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  111     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1993  
Date Detail:
Created Date:  1995-03-28     Completed Date:  1995-03-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  285-94     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Vermont, Burlington.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Administration, Oral
Adult
Affect / drug effects
Behavior / drug effects*
Blood Pressure / drug effects
Cocaine / administration & dosage,  pharmacology*
Dextroamphetamine / pharmacology
Dose-Response Relationship, Drug
Double-Blind Method
Drug Interactions
Ethanol / administration & dosage,  pharmacology*
Euphoria / drug effects
Female
Heart / drug effects*
Heart Rate / drug effects
Humans
Male
Psychomotor Performance / drug effects
Skin Temperature / drug effects
Grant Support
ID/Acronym/Agency:
DA-04545/DA/NIDA NIH HHS; DA-05382/DA/NIDA NIH HHS; DA-05538/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 51-64-9/Dextroamphetamine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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