Document Detail


Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood.
MedLine Citation:
PMID:  10740808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute basophilic leukemia is an uncommon form of acute leukemia, rarely occurring as a de novo disease. We describe a case of de novo acute basophilic leukemia occurring in a 47-year-old man who presented with abnormal liver function tests in the absence of leukemic infiltration of the liver. We postulate that this presentation occurred as a consequence of pathophysiological features of the malignant basophilic blast cells.
Authors:
R A Scolyer; M Brun; J D'Rozario; M Webb
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology     Volume:  32     ISSN:  0031-3025     ISO Abbreviation:  Pathology     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-05-12     Completed Date:  2000-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  52-5     Citation Subset:  IM    
Affiliation:
Department of Anatomical Pathology, Canberra Hospital, Garran, ACT, Australia.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bone Marrow Cells / pathology
Cytarabine / therapeutic use
Cytoplasmic Granules / ultrastructure
Diagnosis, Differential
Drug Therapy, Combination
Fatal Outcome
Humans
Idarubicin / therapeutic use
Immunophenotyping
Karyotyping
Leukemia, Basophilic, Acute / blood,  diagnosis*,  drug therapy,  genetics
Leukemic Infiltration / pathology*
Liver / pathology*
Liver Function Tests*
Male
Middle Aged
Neoplastic Stem Cells / pathology*
Chemical
Reg. No./Substance:
147-94-4/Cytarabine; 58957-92-9/Idarubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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