| Acute atherosis in decidual tissue: not associated with systemic oxidative stress in preeclampsia. | |
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MedLine Citation:
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PMID: 17218009 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The aim of this study was to explore a possible association between the presence of decidual acute atherosis, maternal hyperlipidaemia and oxidative stress in the maternal circulation in preeclamptic and uneventful pregnancies. Decidual tissue was harvested by a vacuum suction technique following delivery of the baby and placenta in 102 caesarean deliveries. Maternal plasma lipid profile and concentration of 8-isoprostane, a marker of oxidative stress, was analysed. Acute atherosis was present in 42% of the preeclamptic patients with identified spiral arteries. CD68 positive foam cells were found in the spiral artery walls in 14% of the normal pregnancies. We have previously demonstrated an elevated plasma level of 8-isoprostane in the preeclampsia group, as compared to the uneventful pregnancy group (218 vs. 354 pg/mL, p=0.02). Presence of acute atherosis was, however, not associated with an elevated level of oxidative stress in the maternal circulation, measured as 8-isoprostane. In conclusion, the presence of decidual vascular changes in the form of acute atherosis is not necessarily paralleled by hyperlipidaemia or augmented oxidative stress in the maternal systemic circulation. This study adds to the notion of preeclampsia being a multifactorial disease with a variety of clinical forms. |
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Authors:
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N K Harsem; B Roald; K Braekke; A C Staff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-01-10 |
Journal Detail:
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Title: Placenta Volume: 28 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 2007 Aug-Sep |
Date Detail:
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Created Date: 2007-07-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 958-64 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Ulleval University Hospital, Kirkeveien 166, 0450 Oslo, Norway. ninakittelsen.harsem@ulleval.no |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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