Document Detail


Acute ascorbic acid and hindlimb skeletal muscle blood flow distribution in old rats: rest and exercise.
MedLine Citation:
PMID:  23181277     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Excess reactive oxygen species are implicated in the impaired peripheral vascular function evident during exercise in older individuals. We tested the hypothesis that an acute infusion of the antioxidant ascorbic acid (AA) in old rats would improve antioxidant capacity and reduce oxidative stress and, therefore, elevate hindlimb muscle blood flow at rest and during treadmill exercise in muscles containing principally type I and IIa muscle fibers. Total and individual hindlimb skeletal muscle blood flow was measured (radiolabeled microspheres) in old rats (26-28 months) at rest (n = 8) and during treadmill exercise (n = 8; 20 m·min(-1), 5% grade) before and after AA treatment (76 mg·(kg body mass)(-1) intra-arterial (i.a.) injection). AA elevated total antioxidant capacity (rest, ∼37%; and exercise, 31%) and reduced oxidative stress (∼26%, exercise only). AA reduced resting total hindlimb muscle blood flow (control, 25 ± 3; AA, 16 ± 2 mL·min(-1)·(100 g)(-1); p < 0.05) and blood flow to 8 of 28 individual muscles with no fiber-type correlation (p > 0.05). During exercise there was no effect of AA on total hindlimb muscle blood flow (control, 154 ± 14; AA, 162 ± 13 mL·min(-1)·(100 g)(-1); p > 0.05) or blood flow to any individual muscle. This disconnect between whole-body antioxidant status and skeletal muscle blood flow in old rats mandates consideration when pursuing antioxidant treatments experimentally or clinically in older populations.
Authors:
Steven W Copp; Peter J Schwagerl; Daniel M Hirai; David C Poole; Timothy I Musch
Related Documents :
22961867 - A differing role of oxidative stress in the regulation of central and peripheral hemody...
6435007 - Oxygen utilization and cardiovascular function in head-injured patients.
7196347 - The possible risks of a copper and an inert intrauterine device situated in the abdomin...
7562657 - Energy cost and locomotive economy of handbike and rowcycle propulsion by persons with ...
18597787 - Mating rates between sterile and wild codling moths (cydia pomonella) in springtime: a ...
3814627 - Advantages of perfluorochemical perfusion in the isolated working rabbit heart preparat...
Publication Detail:
Type:  Journal Article     Date:  2012-11-08
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  90     ISSN:  1205-7541     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1498-505     Citation Subset:  IM    
Affiliation:
a Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506-5802, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of electroacupuncture on exp...
Next Document:  Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of Rh...