Document Detail

Acute applications of noninvasive positive pressure ventilation.
MedLine Citation:
PMID:  12907562     Owner:  NLM     Status:  MEDLINE    
Noninvasive positive-pressure ventilation (NPPV) has been used increasingly to treat acute respiratory failure (ARF). The best indications for its use are ARF in patients with COPD exacerbations, acute pulmonary edema, and immunocompromised states. For these indications, multiple controlled trials have demonstrated that therapy with NPPV avoids intubation and, in the case of COPD and immunocompromised patients, reduces mortality as well. NPPV is used to treat patients with numerous other forms of ARF, but the evidence is not as strong for its use in those cases, and patients must be selected carefully. The best candidates for NPPV are able to protect their airway, are cooperative, and are otherwise medically stable. Success is optimized when a skilled team applies a well-fitted, comfortable interface. Ventilator settings should be adjusted to reduce respiratory distress while avoiding excessive discomfort, patient-ventilator synchrony should be optimized, and adequate oxygenation should be assured. The appropriate application of NPPV in the acute care setting should lead to improved patient outcomes and more efficient resource utilization.
Timothy Liesching; Henry Kwok; Nicholas S Hill
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Chest     Volume:  124     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-08     Completed Date:  2003-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  699-713     Citation Subset:  AIM; IM    
Division of Pulmonary, Critical Care and Sleep Medicine, Brown Medical School, Providence, RI, USA.
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MeSH Terms
Length of Stay
Positive-Pressure Respiration / methods*
Pulmonary Disease, Chronic Obstructive / complications,  therapy*
Randomized Controlled Trials as Topic
Respiratory Distress Syndrome, Adult / classification,  etiology,  therapy*
Comment In:
Chest. 2003 Aug;124(2):428-31   [PMID:  12907525 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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