Document Detail


Acute antianginal hemodynamic effects of nicardipine in coronary artery disease.
MedLine Citation:
PMID:  2301244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To define the short-term effects of intravenous nicardipine on exercise- and pacing-induced myocardial ischemia, 15 men with coronary artery disease were studied. Nicardipine was administered as a 2 mg bolus followed by an infusion, titrated to maintain a 10 to 20 mm Hg decrease in systolic arterial pressure. At rest, nicardipine significantly decreased systemic and coronary vascular resistances and left ventricular end-diastolic pressure but increased coronary blood flow, heart rate, and myocardial oxygen consumption. With bicycle exercise performed to evoke myocardial ischemia, nicardipine prolonged exercise duration, time to of 1 mm ST segment depression, and increased cardiac work to onset of angina in most patients. These changes in cardiac performance were not associated with alteration in the product of systolic pressure and heart rate or with increased left ventricular end-diastolic pressure. During increased heart rate induced by atrial pacing to cause ischemia, the heart rate threshold for myocardial ischemia was not changed by nicardipine. This occurred despite decreased myocardial oxygen consumption, unchanged coronary blood flow, and otherwise similar hemodynamic changes as those observed during exercise. However, left ventricular end-diastolic pressure remained lower and stroke volume increased more after nicardipine with pacing stress when compared with observations before nicardipine with the same heart rate stress. These findings support beneficial antiischemic actions of nicardipine with possible prevention of ischemia-related left ventricular dysfunction.
Authors:
C R Lambert; C J Pepine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  119     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  457-62     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Gainesville Administration Medical Center, FL 32602.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / etiology,  prevention & control*
Cardiac Pacing, Artificial
Coronary Disease / complications,  drug therapy*,  physiopathology
Exercise
Hemodynamics / drug effects*
Humans
Male
Middle Aged
Nicardipine / therapeutic use*
Rest
Time Factors
Chemical
Reg. No./Substance:
55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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