| Acute anterior myocardial infarction in a young male patient homozygous for the factor V Leiden mutation. | |
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MedLine Citation:
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PMID: 20675997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are several reports on the association between the factor V Leiden mutation and acute myocardial infarction (AMI) in young patients, in particular young males. A 28-year-old male patient was admitted with severe chest pain of new onset. He was an active smoker. His father had a history of coronary artery disease and AMI after the age of 45 years. There were no other major coronary risk factors. His electrocardiogram showed ST-segment elevation in the precordial leads V1 to V5. His blood pressure, pulse rate, and other clinical parameters were stable. Emergency coronary angiography showed a significant narrowing in the mid-portion of the left anterior descending (LAD) artery with a moderate intracoronary thrombus, and no or minimal atherosclerosis. The other coronary arteries were normal. Direct stenting was performed for the culprit lesion, which resulted in relief of obstruction and significant improvement in the LAD artery. DNA samples isolated from the peripheral blood were analyzed by polymerase chain reaction and the patient was found to be homozygous for the factor V Leiden mutation. Transthoracic echocardiography before discharge showed only mild hypokinesis of the anterior and apical segments. |
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Authors:
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Omer Satiroğlu; Mutlu Vural; Ibrahim Uyar; Mehmet Bostan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır Volume: 38 ISSN: 1016-5169 ISO Abbreviation: Turk Kardiyol Dern Ars Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426239 Medline TA: Turk Kardiyol Dern Ars Country: Turkey |
Other Details:
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Languages: eng Pagination: 194-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Medicine Faculty of Rize University, Rize, Turkey. omersatiroglu@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Coronary Vessels / pathology Electrocardiography Factor V / genetics* Homozygote Humans Male Mutation Myocardial Infarction / etiology*, pathology, radiography Stents |
| Chemical | |
Reg. No./Substance:
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0/factor V Leiden; 9001-24-5/Factor V |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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