Document Detail

Acute anterior myocardial infarction as first manifestation of acute myeloid leukemia.
MedLine Citation:
PMID:  11757728     Owner:  NLM     Status:  MEDLINE    
A 42-year-old man was admitted with heavy retrosternal pain lasting 30 min. Electrocardiography showed typical signs of acute anterior myocardial infarction. The patient reported only attacks of coughing for a couple of days, and no serious diseases. The physical examination was normal. Laboratory tests showed a white blood cell count of 45/nl, platelet count of 58/nl, and hemoglobin of 14.4 g/dl. Blood chemistry showed elevated lactic dehydrogenase (413 U/l) but no elevation in creatine phosphokinase or glutamic-oxaloacetic transaminase. Therefore no thrombolysis was administered, but coronary angiography was performed. This showed a long-distance, subtotal thrombotic occlusion of the left anterior descending artery. After percutaneous transluminal coronary angioplasty and implantation of serial stents a normal perfusion of the artery was observed. The patient's blood and bone marrow films revealed acute myeloid leukemia FAB M2. Various conditions can cause a myocardial infarction in leukemias. We discuss the clinical management and the possible reasons for a subtotal thrombotic occlusion of the coronary artery.
U Jachmann-Jahn; O A Cornely; U Laufs; H W Höpp; I Meuthen; M Krakau; B O'Brien
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of hematology     Volume:  80     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-06     Completed Date:  2001-12-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  677-81     Citation Subset:  IM    
Medizinische Klinik, Krankenhaus Köln-Holweide, Cologne, Germany.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  therapeutic use
Blood Coagulation Disorders / complications
Bone Marrow Cells / pathology
Coronary Angiography
Drug Administration Schedule
Leukemia, Myeloid, Acute / complications,  diagnosis*,  drug therapy
Myocardial Infarction / diagnosis*,  etiology,  radiography

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