| Acute amitriptyline withdrawal and hyponatraemia. A case report. | |
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MedLine Citation:
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PMID: 8471189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The tricyclic antidepressants (TCAs) are commonly used in the treatment of depression and, perhaps due to the nature of the condition being treated, figure prominently in cases of deliberate overdosage, where the toxicity of amitriptyline has been well established. However, the abrupt cessation of TCA administration can also be detrimental to the patient, triggering withdrawal phenomena often characterised by an exacerbation of the symptoms for which the patient was originally treated. We present a biochemically proven case of amitriptyline withdrawal where the clinical features at presentation made it difficult to distinguish from acute toxicity. The patient's neurological signs and distended bladder suggested amitriptyline toxicity, whereas the history and signs of cholinergic hyperactivity were consistent with acute withdrawal. The diagnosis was confirmed at a later date when further history and a biochemical analysis of plasma TCA concentrations became available. Hyponatraemia may have exacerbated the condition of the patient, whether or not it was caused by amitriptyline. |
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Authors:
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P Davison; J Wardrope |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Drug safety : an international journal of medical toxicology and drug experience Volume: 8 ISSN: 0114-5916 ISO Abbreviation: Drug Saf Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-05-20 Completed Date: 1993-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9002928 Medline TA: Drug Saf Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 78-80 Citation Subset: IM |
Affiliation:
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Accident and Emergency Department, Northern General Hospital, Sheffield, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amitriptyline / adverse effects* Humans Hyponatremia / chemically induced* Male Middle Aged Substance Withdrawal Syndrome / etiology* |
| Chemical | |
Reg. No./Substance:
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50-48-6/Amitriptyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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