Document Detail

Acute allergic interstitial pneumonitis induced by hydrochlorothiazide.
MedLine Citation:
PMID:  2049694     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the clinical features of 4 unpublished cases and 26 published cases of acute allergic interstitial pneumonitis induced by hydrochlorothiazide (HCT).
DATA SOURCES: The unpublished cases were found in the database of the Drug Adverse Reaction Program, Health Protection Branch, Department of National Health and Welfare, and the database of the Programme conjoint de pharmacovigilance, in Quebec. The published cases were retrieved from MEDLINE and EMBASE.
STUDY SELECTION: Reported cases were selected if they were sufficiently documented. All published cases were selected because a differential diagnosis had been made in each one.
DATA SYNTHESIS: The onset was acute and dramatic; the average time to onset of symptoms was 44 minutes. Sex was a predominant risk factor, since 27 (90%) of the 30 patients were women. The average age was 56 years; thus, most of the women were postmenopausal. Over two-thirds of the patients had one to three positive prechallenges or rechallenges, 3 of the 52 documented adverse events occurred after a voluntary rechallenge, some were life-threatening and necessitated mechanical ventilation, and 1 was fatal. Treatment was supportive; avoidance of HCT was the only prevention.
CONCLUSION: Acute allergic interstitial pneumonitis due to HCT is extremely rare and potentially fatal. Such a reaction can be diagnosed only if the clinician suspects it when presented with a case of unexplained acute pulmonary edema.
P Biron; J Dessureault; E Napke
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Review    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  145     ISSN:  0820-3946     ISO Abbreviation:  CMAJ     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-07-25     Completed Date:  1991-07-25     Revised Date:  2012-05-09    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  28-34     Citation Subset:  AIM; IM    
Department of Pharmacology, Université de Montréal, PQ.
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MeSH Terms
Acute Disease
Aged, 80 and over
Drug Hypersensitivity / etiology*
Hydrochlorothiazide / adverse effects*
Middle Aged
Pulmonary Fibrosis / chemically induced*
Sex Factors
Reg. No./Substance:
Erratum In:
Can Med Assoc J 1991 Sep 1;145(5):391

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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