| Acute airway changes induced by coughing. | |
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MedLine Citation:
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PMID: 6691909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of voluntary coughs on specific conductance measurements were studied in normal, atopic and asthmatic subjects before and after bronchoconstriction with histamine. The responses were variable, the most frequent change being temporary bronchodilation in the 30 seconds after a voluntary cough in the presence of histamine-induced bronchoconstriction. The effects of the two components of coughing, namely a full inhalation and a cough without a preceding deep inhalation, were studied in a similar manner. After challenge with histamine had reduced specific conductance by approximately 50%, full inhalations produced a temporary increase in conductance. Modified coughs without deep inhalation after histamine most often resulted in a temporary small decrease in conductance. One atopic subject showed marked, prolonged airway narrowing after a single full inhalation before histamine. We conclude that the major effects on airway smooth muscle produced by coughs result from the deep inhalation. In challenge studies coughs may affect subsequent airways resistance measurements. Such brief changes are not clinically important but may affect the results of inhalation challenge studies. Occasionally individuals show more prolonged bronchoconstriction after such manoeuvres. |
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Authors:
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P J Rees; T J Clark |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of diseases of the chest Volume: 78 ISSN: 0007-0971 ISO Abbreviation: Br J Dis Chest Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-03-20 Completed Date: 1984-03-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7511123 Medline TA: Br J Dis Chest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 55-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance* Asthma / physiopathology Bronchi / drug effects Bronchial Provocation Tests Cough / physiopathology* Histamine / pharmacology Humans Respiratory Hypersensitivity / physiopathology |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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