Document Detail


Acute administration of bromocriptine abolishes the hyperprolactinemic response induced by submaximal exercise in man.
MedLine Citation:
PMID:  1490255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effective control of hypophysial prolactin (PRL) secretion with a pharmacological agent is a prerequisite for the investigation of the role of hyperprolactinemia observed during exercise. Using bromocriptine, a potent inhibitor of PRL secretion, this study established the proper experimental conditions whereby any significant increase in plasma PRL level can be prevented and basal circulating levels maintained during physical exercise. On three occasions at weekly intervals, 15 male adults, separated into two groups, exercised on an ergocycle (40 min at 65% VO2max) either 1 or 3 h after ingesting either placebo or 1.25 or 2.50 mg of bromocriptine mesylate (Parlodel; Sandoz Canada Inc., Dorval, Qué.). Under all conditions, the plasma PRL elevation observed during exercise after placebo was prevented by the administration of bromocriptine. Resting plasma PRL levels were maintained when exercise was performed 1 h after bromocriptine ingestion, but were significantly reduced when exercise was performed 3 h after administration of either bromocriptine dosages. Considering the primary and secondary effects observed, 1.25 mg of bromocriptine administered 1 h before exercise provides suitable experimental conditions to investigate the role of the increase in plasma PRL during physical exercise.
Authors:
P Boisvert; G R Brisson; F Péronnet; R Gareau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  70     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-03-02     Completed Date:  1993-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1379-83     Citation Subset:  IM    
Affiliation:
Physical Education Department, Université de Montréal, Qué., Canada.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Blood Pressure / physiology
Bromocriptine / administration & dosage,  pharmacology*
Exercise / physiology*
Heart Rate / physiology
Humans
Hyperprolactinemia / etiology,  prevention & control*
Male
Time Factors
Chemical
Reg. No./Substance:
25614-03-3/Bromocriptine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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