Document Detail

Acute action of aminophylline in patients with amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  17489939     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study investigated whether aminophylline has an acute effect on the muscle performance of patients with amyotrophic lateral sclerosis (ALS). The study was a randomized, double-blind, crossover against placebo. MATERIALS AND METHODS: Twenty-five patients (48.5 +/- 14.1 years) with ALS were evaluated by means of forced vital capacity (FVC), maximal mouth inspiratory and expiratory pressures (P(Imax)/P(Emax)) and endurance, maximum voluntary ventilation (MVV) and handgrip strength (HS); variables were measured before and after the patients received an intravenous infusion of aminophylline or placebo. RESULTS: MVV (P<0.02) and HS of the right and left hands (P=0.05) increased after aminophylline infusion. There was a positive correlation between FVC and P(Imax) (r=0.80; P<0.05); between MVV and P(Imax) post-aminophylline, respectively (r=0.77; P<0.05). Serum aminophylline levels ranged from 5.3 to 10.5 microg/mL (mean 7.30). CONCLUSION: The acute administration of aminophylline improves the endurance of respiratory muscles and increases handgrip strength in patients with ALS.
M C Berto; S C Filha; A Camelier; F W Rosa; A de Souza Bulle Oliveira; J R Jardim
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  115     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-10     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  IM    
Respiratory and Neurology Divisions, UNIFESP, Federal University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Aminophylline / administration & dosage*,  blood
Amyotrophic Lateral Sclerosis / complications*
Bronchodilator Agents / administration & dosage*,  blood
Cross-Over Studies
Hand Strength
Infusions, Intravenous
Middle Aged
Muscle Strength / drug effects
Respiratory Insufficiency / drug therapy*,  etiology
Respiratory Muscles / drug effects,  physiology
Treatment Outcome
Vital Capacity / drug effects
Reg. No./Substance:
0/Bronchodilator Agents; 317-34-0/Aminophylline

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