Document Detail


Acute action of aminophylline in patients with amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  17489939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study investigated whether aminophylline has an acute effect on the muscle performance of patients with amyotrophic lateral sclerosis (ALS). The study was a randomized, double-blind, crossover against placebo. MATERIALS AND METHODS: Twenty-five patients (48.5 +/- 14.1 years) with ALS were evaluated by means of forced vital capacity (FVC), maximal mouth inspiratory and expiratory pressures (P(Imax)/P(Emax)) and endurance, maximum voluntary ventilation (MVV) and handgrip strength (HS); variables were measured before and after the patients received an intravenous infusion of aminophylline or placebo. RESULTS: MVV (P<0.02) and HS of the right and left hands (P=0.05) increased after aminophylline infusion. There was a positive correlation between FVC and P(Imax) (r=0.80; P<0.05); between MVV and P(Imax) post-aminophylline, respectively (r=0.77; P<0.05). Serum aminophylline levels ranged from 5.3 to 10.5 microg/mL (mean 7.30). CONCLUSION: The acute administration of aminophylline improves the endurance of respiratory muscles and increases handgrip strength in patients with ALS.
Authors:
M C Berto; S C Filha; A Camelier; F W Rosa; A de Souza Bulle Oliveira; J R Jardim
Related Documents :
10776429 - Positive end-expiratory pressure and response to inhaled nitric oxide: changing nonresp...
6156499 - The effect of peep ventilation on hemodynamics and regional blood flow with special reg...
9817719 - Effect of different pressure levels on the dynamics of lung collapse and recruitment in...
23839559 - Does increasing end-tidal carbon dioxide during laparoscopic cholecystectomy matter?
11528599 - Hemodynamic effects of positive end-expiratory pressure during partial liquid ventilati...
7031289 - Influence of lipid infusion (0.4 g/kg/hr) and positive end expiratory pressure (8 cm h2...
23815169 - Distinct responses to mechanical grinding and hydrostatic pressure in luminescent chrom...
7910029 - Life survival and cardiovascular structures following selective beta-blockade in sponta...
23882329 - Valsalva maneuver: shortest optimal expiratory strain duration.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  115     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-10     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  IM    
Affiliation:
Respiratory and Neurology Divisions, UNIFESP, Federal University of São Paulo, São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aminophylline / administration & dosage*,  blood
Amyotrophic Lateral Sclerosis / complications*
Bronchodilator Agents / administration & dosage*,  blood
Cross-Over Studies
Female
Hand Strength
Humans
Infusions, Intravenous
Male
Middle Aged
Muscle Strength / drug effects
Respiratory Insufficiency / drug therapy*,  etiology
Respiratory Muscles / drug effects,  physiology
Treatment Outcome
Vital Capacity / drug effects
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 317-34-0/Aminophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hormonal contraceptives as a risk factor for cerebral venous and sinus thrombosis.
Next Document:  Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patien...