Document Detail


Acute Wilson disease associated with E beta-thalassemia.
MedLine Citation:
PMID:  19131782     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report on an 11-year-old girl with concomitant Ebeta thalassemia (EbetaT) and Wilson disease (WD). She was diagnosed with EbetaT at 2 years of age, but the coexistence of WD could only be established at 11 years. The diagnosis of the later was based on the clinical presentation of hepatitis and severe Coomb's negative hemolytic anemia, coupled with laboratory evidence of WD. To our knowledge, this is the first report on the cooccurrence of EbetaT and WD. As both the conditions are associated with variable degrees of hemolysis, WD in the setting of EbetaT may remain masked and consequently remain undiagnosed for a long time. Sudden, severe hemolysis in a patient of thalassemia may be explained by the coexistence of additional pathology, in this case WD.
Authors:
Rajoo Thapa; Kabita Mukherjee
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  30     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-02-03     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  925-7     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, The Institute of Child Health, Kolkata, West Bengal, India. rajoothapa@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Child
Coombs' Test
Diagnosis, Differential
Female
Hemolysis
Hepatolenticular Degeneration / complications*,  diagnosis
Humans
beta-Thalassemia / complications*,  diagnosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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