| The Acute Salivary Ghrelin Response to a Psychosocial Stress Is Enhanced in Symptomatic Patients with Bulimia Nervosa: A Pilot Study. | |
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MedLine Citation:
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PMID: 23095350 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Stress is a precipitating factor for both binge eating and bulimia nervosa (BN); however, the biological mechanisms through which it may trigger binge eating are poorly understood. There is evidence that the adrenal hormone cortisol and the gastric peptide ghrelin might be involved in stress-induced food ingestion. We hypothesized that symptomatic patients with BN might disclose deranged responses of ghrelin and/or cortisol to stressors and that this could be related to their binge-eating behaviour. Methods: Here we investigated salivary cortisol and ghrelin responses to the Trier Social Stress Test (TSST) in 10 women with acute BN and 10 age-matched healthy females. Eating-related psychopathology and behaviours were assessed by self-report measures. Results: No significant differences emerged between bulimic patients and healthy controls in the pre-stress salivary levels of both cortisol and ghrelin. The BN patients displayed normal cortisol but enhanced ghrelin responses to TSST. No significant correlations emerged between stress-induced salivary hormone changes and self-report measures of binge eating. Conclusion: To our knowledge, this is the first study showing deranged salivary ghrelin reactivity to a psychosocial stressor in symptomatic patients with BN. The extent to which this could contribute to the binge-eating behaviour of BN subjects awaits clarification. |
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Authors:
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Palmiero Monteleone; Alfonso Tortorella; Pasquale Scognamiglio; Ismene Serino; Alessio Maria Monteleone; Mario Maj |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-23 |
Journal Detail:
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Title: Neuropsychobiology Volume: 66 ISSN: 1423-0224 ISO Abbreviation: Neuropsychobiology Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7512895 Medline TA: Neuropsychobiology Country: - |
Other Details:
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Languages: ENG Pagination: 230-236 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Chair of Psychiatry, Department of Medicine and Surgery, University of Salerno, Salerno, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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