Document Detail


Acute ST-segment elevation myocardial infarction complicating amoxycillin-induced anaphylaxis: a case report.
MedLine Citation:
PMID:  17303266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 70-year-old man experienced an amoxycillin-induced anaphylactic reaction complicated by acute inferior myocardial infarction with transient ST-segment elevation. There was a spontaneous resolution of ST-segment elevation and the patient was treated for anaphylaxis. Coronary angiography showed severe obstructive coronary atherosclerosis, but not involving the infarct-related artery. Percutaneous coronary intervention of the affected artery was then performed and the patient was discharged three days later. Acute ST-elevation myocardial infarction has been described as one of the severe, still rare cardiovascular complications of anaphylaxis. In the present case, according to the previous reports, the main pathogenetic mechanism involved appears to have been coronary vasospasm probably caused by the release of potent vasoactive mast cell derived mediators in the setting of anaphylaxis.
Authors:
Francesca Del Furia; Loreno Querceto; Sergio Testi; Giovanni Maria Santoro
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Publication Detail:
Type:  Case Reports; Letter     Date:  2007-02-15
Journal Detail:
Title:  International journal of cardiology     Volume:  117     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-19     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e37-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Amoxicillin / adverse effects*
Anaphylaxis / chemically induced*,  diagnosis,  therapy
Coronary Stenosis / complications,  diagnosis,  therapy
Drug Hypersensitivity / complications*,  diagnosis,  therapy
Electrocardiography
Humans
Male
Myocardial Infarction / complications*,  diagnosis
Treatment Outcome
Chemical
Reg. No./Substance:
26787-78-0/Amoxicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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