Document Detail


The Acute Response of Apoptosis and Migration to Resistance Exercise Is Protocol-Dependent.
MedLine Citation:
PMID:  24816885     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of the present study was to compare the acute effects of resistance exercise (RE) designed for hypertrophy or local muscle endurance (LME) on CD4+ and CD8+ T cell apoptosis and migration. 14 untrained subjects (age 20.5±0.8 years, body mass 70.0±12.8 kg, body mass index 24.0±3.2 kg/m2), women (N=11) and men (N=3) completed 2 RE sessions (3 sets of 9 exercises) designed for hypertrophy at 10 repetitions maximum (RM) and LME at 60% of 10RM with 1-min rest-intervals between sets and exercises. The investigated lymphocytes were: CD4+, CD4+/CD69RA+, CD8+ and CD8+/CD69RA+ with cell surface markers annexin V and CX3CR1 analyzed by flow cytometry. Percentage of CD4+ positive for annexin V+ were higher immediately following and 24 h after the hypertrophy protocol as compared with LME, while CD4+ positive for CX3CR1 were higher immediately after and lower at the 24 h time point after LME as compared with the hypertrophy session. CD8+ lymphocytes responded similarly to the hypertrophy and LME protocols with elevations in both cellular migration and cell death immediately following and 24 h after the bouts (p≤0.05). Considering that the acute response of CD4+ lymphocytes to RE is protocol-dependent, a gradual adaptation to a hypertrophy program could minimize the effect on CD4+ lymphocytes and reduce the potential susceptibility to antigens during this timeframe. This would also be interesting for a RE program designed for LME based on the observed CD8+ lymphocyte response.
Authors:
J Prestes; G B Pereira; R A Tibana; J W Navalta
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-9
Journal Detail:
Title:  International journal of sports medicine     Volume:  -     ISSN:  1439-3964     ISO Abbreviation:  Int J Sports Med     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
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