| The acute respiratory distress syndrome: pathogenesis and treatment. | |
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MedLine Citation:
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PMID: 20936936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute respiratory distress syndrome (ARDS) causes 40% mortality in approximately 200,000 critically ill patients annually in the United States. ARDS is caused by protein-rich pulmonary edema that causes severe hypoxemia and impaired carbon dioxide excretion. The clinical disorders associated with the development of ARDS include sepsis, pneumonia, aspiration of gastric contents, and major trauma. The lung injury is caused primarily by neutrophil-dependent and platelet-dependent damage to the endothelial and epithelial barriers of the lung. Resolution is delayed because of injury to the lung epithelial barrier, which prevents removal of alveolar edema fluid and deprives the lung of adequate quantities of surfactant. Lymphocytes may play a role in resolution of lung injury. Mortality has been markedly reduced with a lung-protective ventilatory strategy. However, there is no effective pharmacologic therapy, although cell-based therapy and other therapies currently being tested in clinical trials may provide novel treatments for ARDS. |
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Authors:
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Michael A Matthay; Rachel L Zemans |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annual review of pathology Volume: 6 ISSN: 1553-4014 ISO Abbreviation: Annu Rev Pathol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-25 Completed Date: 2011-04-25 Revised Date: 2012-03-14 |
Medline Journal Info:
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Nlm Unique ID: 101275111 Medline TA: Annu Rev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 147-63 Citation Subset: IM |
Affiliation:
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The Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, 94143, USA. michael.matthay@ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Pulmonary Alveoli / immunology*, pathology* Respiratory Distress Syndrome, Adult* / etiology, pathology, therapy |
| Grant Support | |
ID/Acronym/Agency:
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K08 HL103772-01/HL/NHLBI NIH HHS; P01AI1053194/AI/NIAID NIH HHS; R37HL51854/HL/NHLBI NIH HHS; R37HL51856/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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