| Acute promyelocytic leukemia treated with idarubicin complicated by focal segmental glomerulosclerosis. | |
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MedLine Citation:
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PMID: 20048687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors report a 9-year-old boy presenting with a left cerebral ischemic infarction as the first manifestation of acute promyelocytic leukemia. During consolidation chemotherapy, the patient developed nephrotic syndrome and a renal biopsy revealed focal segmental glomerulosclerosis (FSGS). Remission in bone marrow was achieved with chemotherapy, however, new intracranial ischemic areas developed on follow-up. Acute promyelocytic leukemia complicated by FSGS has not been previously reported in children. There may be a relationship between anthracycline treatment and FSGS. Thrombosis could be related with both leukemia and nephrotic syndrome, here thrombosis was the initial symptom, before FSGS was diagnosed. |
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Authors:
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Safa Bariş; Mine Ozdil; Nilüfer Topal; Omer Doğru; Nihal Ozdemir; Lale Sever; Sait Albayram; Işin Kiliçaslan; Tiraje Celkan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-03-30 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: e82-4 Citation Subset: IM |
Affiliation:
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Departments of Pediatrics, Pediatric Hematology-Oncology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibiotics, Antineoplastic
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adverse effects* Child Glomerulosclerosis, Focal Segmental / etiology* Humans Idarubicin / adverse effects* Leukemia, Promyelocytic, Acute / complications, drug therapy* Male Nephrotic Syndrome / etiology Thrombosis / etiology |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 58957-92-9/Idarubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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