| Acute Pancreatitis in a Patient Receiving Vildagliptin. | |
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MedLine Citation:
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PMID: 21324812 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To describe the first reported case of acute pancreatitis in a patient receiving vildagliptin.Methods: We present the biochemical and radiographic findings of a 61 year-old woman who presented with severe abdominal pain and was found to have acute pancreatitis. This occurred five weeks after the commencement of vildagliptin, a dipeptidyl peptidase IV inhibitor, for the treatment of type 2 diabetes.Results: Pancreatic enzymes were significantly elevated (ie amylase 1205 U/L [<110]; lipase 8846 U/L [<3000]) and abdominal CT scan demonstrated diffuse pancreatic swelling, cyst formation and necrosis within the body of the pancreas. In the absence of an identifiable cause for the patient's pancreatitis, vildagliptin was considered a potential trigger and on ceasing this agent, the patient recovered from her condition.Conclusion: Although incretin-based therapy is effective in the treatment of type 2 diabetes mellitus, emerging reports of acute pancreatitis in patients receiving sitagliptin and exenatide have prompted the FDA to issue an alert on these drugs. This appears to be the first reported case of acute pancreatitis in a patient receiving vildagliptin and supports the possibility that acute pancreatitis may be a rare effect of incretin-based therapy. |
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Authors:
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Christian M Girgis; Bernard L Champion |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-16 |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: - ISSN: 1934-2403 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: - |
Other Details:
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Languages: ENG Pagination: 1-6 Citation Subset: - |
Affiliation:
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Department of Medicine, University of Sydney. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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