| Acute pancreatitis during pregnancy. | |
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MedLine Citation:
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PMID: 19747985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Acute pancreatitis is rare during pregnancy; limited data are available about maternal and fetal outcomes. We investigated the effects of acute pancreatitis during pregnancy on fetal outcome. METHODS: This retrospective cohort study, performed at a single academic center, included consecutive pregnant women who presented with (n = 96) or developed acute pancreatitis in the hospital (n = 7) in 2000-2006 (mean age, 26 y). Patient histories and clinical data were collected from medical records. RESULTS: Of the 96 patients with spontaneous pancreatitis, 4 had complications: 1 patient in the first trimester had acute peripancreatic fluid collection, and 3 patients in the third trimester developed disseminated vascular coagulation (DIC). None of these patients achieved term pregnancy, and 1 of the patients with DIC died. Endoscopic retrograde cholangiopancreatography (ERCP) was performed in 23 patients with acute pancreatitis; post-ERCP pancreatitis was diagnosed in 4 patients (a total of 11 patients developed ERCP-associated pancreatitis). Term pregnancy was achieved in 73 patients (80.2%). Patients who developed pancreatitis in the first trimester had the lowest percentage of term pregnancy (60%) and highest risks of fetal loss (20%) and preterm delivery (16%). Of the patients with pancreatitis in the second and third trimesters, only one had fetal loss. Fetal malformations were not observed. CONCLUSIONS: The majority of pregnant patients with acute pancreatitis did not have complications; most adverse fetal outcomes (fetal loss and preterm delivery) occurred during the first trimester. Acute pancreatitis, complicated by DIC, occurred most frequently in the third trimester and was associated with poor fetal and maternal outcomes. |
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Authors:
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Shou-Jiang Tang; Edmundo Rodriguez-Frias; Sundeep Singh; Marlyn J Mayo; Saad F Jazrawi; Jayaprakash Sreenarasimhaiah; Luis F Lara; Don C Rockey |
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Publication Detail:
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Type: Journal Article Date: 2009-09-10 |
Journal Detail:
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Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 8 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-04-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
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Languages: eng Pagination: 85-90 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Gastroenterology, Hepatology & Endoscopy, Trinity Mother Frances Hospitals and Clinics, Tyler, Texas, USA. tangs@tmfhs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cohort Studies Disseminated Intravascular Coagulation / epidemiology Female Fetal Mortality* Humans Pancreatitis, Acute Necrotizing / complications, epidemiology* Pregnancy Pregnancy Complications / epidemiology* Premature Birth* Retrospective Studies Treatment Outcome Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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